Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3634267..3634972 Replicon chromosome
Accession NZ_CP066759
Organism Escherichia coli O157:H7 strain ECP19-198

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag JG533_RS18470 Protein ID WP_000539519.1
Coordinates 3634267..3634653 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JG533_RS18475 Protein ID WP_001280945.1
Coordinates 3634643..3634972 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG533_RS18450 3630271..3630897 + 627 WP_001295292.1 glutathione S-transferase GstB -
JG533_RS18455 3630894..3632009 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
JG533_RS18460 3632120..3632503 - 384 WP_000497137.1 biofilm formation regulator BssR -
JG533_RS18465 3632716..3634041 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JG533_RS18470 3634267..3634653 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG533_RS18475 3634643..3634972 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JG533_RS18480 3635042..3636370 - 1329 WP_000086905.1 GGDEF domain-containing protein -
JG533_RS18485 3636378..3638726 - 2349 WP_000950320.1 EAL domain-containing protein -
JG533_RS18490 3638904..3639815 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T184983 WP_000539519.1 NZ_CP066759:3634267-3634653 [Escherichia coli O157:H7]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T184983 NZ_CP087859:c100642-100307 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT184983 WP_001280945.1 NZ_CP066759:3634643-3634972 [Escherichia coli O157:H7]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT184983 NZ_CP087859:c100317-100036 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References