Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3468106..3468584 Replicon chromosome
Accession NZ_CP066759
Organism Escherichia coli O157:H7 strain ECP19-198

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JG533_RS17730 Protein ID WP_001303876.1
Coordinates 3468297..3468584 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JG533_RS17725 Protein ID WP_000536233.1
Coordinates 3468106..3468297 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG533_RS17690 3463510..3464280 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JG533_RS17695 3464302..3465048 - 747 WP_000788751.1 ATP-binding protein -
JG533_RS17700 3465055..3466146 - 1092 WP_001205823.1 hypothetical protein -
JG533_RS17705 3466225..3466680 + 456 WP_000273724.1 hypothetical protein -
JG533_RS17710 3466887..3467312 - 426 WP_000693855.1 Rha family transcriptional regulator -
JG533_RS17715 3467296..3467568 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
JG533_RS17720 3467677..3468078 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JG533_RS17725 3468106..3468297 + 192 WP_000536233.1 hypothetical protein Antitoxin
JG533_RS17730 3468297..3468584 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG533_RS17735 3468862..3469017 + 156 WP_000379575.1 DUF1391 family protein -
JG533_RS17740 3469159..3469548 + 390 WP_000394511.1 hypothetical protein -
JG533_RS17745 3469735..3469920 - 186 WP_001133046.1 hypothetical protein -
JG533_RS17750 3470494..3470682 + 189 WP_000413705.1 cell division inhibition protein DicB -
JG533_RS17755 3470679..3470870 + 192 WP_001098307.1 DUF1482 family protein -
JG533_RS17760 3470964..3473435 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T184982 WP_001303876.1 NZ_CP066759:3468297-3468584 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T184982 NZ_CP087856:2630318-2630653 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT184982 WP_000536233.1 NZ_CP066759:3468106-3468297 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT184982 NZ_CP087856:2630643-2630924 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References