Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2429401..2429872 | Replicon | chromosome |
| Accession | NZ_CP066759 | ||
| Organism | Escherichia coli O157:H7 strain ECP19-198 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | JG533_RS12050 | Protein ID | WP_001303511.1 |
| Coordinates | 2429401..2429679 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | JG533_RS12055 | Protein ID | WP_001302048.1 |
| Coordinates | 2429681..2429872 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JG533_RS12020 | 2424626..2424877 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| JG533_RS12025 | 2424950..2427421 | - | 2472 | WP_000048458.1 | exonuclease | - |
| JG533_RS12030 | 2427514..2427705 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| JG533_RS12035 | 2427702..2427890 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| JG533_RS12040 | 2428459..2428677 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| JG533_RS12045 | 2428749..2429048 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| JG533_RS12050 | 2429401..2429679 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JG533_RS12055 | 2429681..2429872 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| JG533_RS12060 | 2429893..2430264 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| JG533_RS12065 | 2430362..2430664 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| JG533_RS12070 | 2430661..2431086 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| JG533_RS12075 | 2431109..2432071 | + | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| JG533_RS12080 | 2432078..2432818 | + | 741 | WP_000788938.1 | ATP-binding protein | - |
| JG533_RS12085 | 2432844..2433613 | + | 770 | Protein_2364 | DUF1627 domain-containing protein | - |
| JG533_RS12090 | 2433629..2434024 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| JG533_RS12095 | 2434081..2434665 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2422240..2467693 | 45453 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T184979 WP_001303511.1 NZ_CP066759:c2429679-2429401 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T184979 NZ_CP087856:2052863-2053123 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT184979 WP_001302048.1 NZ_CP066759:c2429872-2429681 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT184979 NZ_CP087856:2053104-2053439 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|