Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 58593..59152 Replicon plasmid unnamed1
Accession NZ_CP066757
Organism Escherichia coli O157:H7 strain ECP19-798

Toxin (Protein)


Gene name relE Uniprot ID O82928
Locus tag JG530_RS27165 Protein ID WP_000421248.1
Coordinates 58877..59152 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag JG530_RS27160 Protein ID WP_001178089.1
Coordinates 58593..58877 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG530_RS27120 53790..54350 + 561 WP_000840472.1 fertility inhibition protein FinO -
JG530_RS27125 54483..54695 + 213 WP_001302189.1 ANR family transcriptional regulator -
JG530_RS27130 54940..55401 + 462 WP_001233853.1 thermonuclease family protein -
JG530_RS27135 55447..55656 + 210 WP_001302200.1 hemolysin expression modulator Hha -
JG530_RS27140 55694..56032 + 339 WP_000766796.1 hypothetical protein -
JG530_RS27145 56272..56583 + 312 WP_199557132.1 replication regulatory protein RepA -
JG530_RS27150 56761..56835 + 75 WP_001370046.1 RepA leader peptide Tap -
JG530_RS27155 56828..57685 + 858 WP_000130945.1 incFII family plasmid replication initiator RepA -
JG530_RS27160 58593..58877 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
JG530_RS27165 58877..59152 + 276 WP_000421248.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG530_RS27170 59247..59453 + 207 WP_001105064.1 hypothetical protein -
JG530_RS27175 59552..59767 - 216 Protein_64 transposase -
JG530_RS27180 59768..60376 - 609 Protein_65 IS3 family transposase -
JG530_RS27185 60376..60791 - 416 Protein_66 transposase zinc-binding domain-containing protein -
JG530_RS27190 60791..60976 - 186 WP_001302179.1 hypothetical protein -
JG530_RS27195 61137..63347 + 2211 Protein_68 catalase/peroxidase KatP -
JG530_RS27200 63390..63575 + 186 WP_199557133.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - hlyC / hlyA / hlyB / hlyD / toxB / toxB / toxB / toxB / katA / toxB / toxB / toxB / toxB / toxB / espP / stcE / exeE / exeG 1..127648 127648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10735.42 Da        Isoelectric Point: 9.9324

>T184961 WP_000421248.1 NZ_CP066757:58877-59152 [Escherichia coli O157:H7]
MELKWSSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T184961 NZ_CP087854:1477652-1477834 [Moraxella bovis]
ATGAAGTATTCAGAGTTTCAAAGGTGGCTATTGGCACAAGGGGCAACGGTAAACAAGCAAGGCGGTAAAGGCTCGCACCG
TAAAGTTACCCTAAATGGCAAAACCACCACTTTCCCTTATCACGGCAGTAAAGAGATTGGGGAAGGACTAAGAAAGAAAA
TTTTAAAAGACTTGGATTTATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10474.89 Da        Isoelectric Point: 5.6558

>AT184961 WP_001178089.1 NZ_CP066757:58593-58877 [Escherichia coli O157:H7]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT184961 NZ_CP087854:1477896-1478309 [Moraxella bovis]
ATGTACTATCCTGCTACTTTTACCCCTGATACCAATGATACTTTTTTGGTGGCGTTTCGTGATATTCCCGAAGCGGTGGG
CGTGGGTGAAACCTTTGAAATCGCCTACCAATCCGCCCTTGACGGCTTAGAAACGGCATTTAGCATCTATATGGACGAAC
GCAAGCCAATCCCCGCCCCCAGTGAGCTGTCTGACGGCGAACACGCCATTTATTTGCCTGTGGCGGTACAGACCAAACTT
GCCTTATATCACGAAATGCTAGCCCAAGGCGTTACTAAGGCGGAGCTGGCTCGCCGTCTGTCTGTCAATCAAAAACAAAT
TGATAGACTTTGGGACGTGAGCCACTCCACCAAATTAGAATTTTTGGAAAAGGCGTTTAGCGTGCTAGGCAAACGCCTAT
CCCTAGCCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z6FAZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References