Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3497690..3498168 Replicon chromosome
Accession NZ_CP066756
Organism Escherichia coli O157:H7 strain ECP19-798

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JG530_RS17950 Protein ID WP_001303876.1
Coordinates 3497881..3498168 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JG530_RS17945 Protein ID WP_000536233.1
Coordinates 3497690..3497881 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG530_RS17910 3493094..3493864 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JG530_RS17915 3493886..3494632 - 747 WP_000788751.1 ATP-binding protein -
JG530_RS17920 3494639..3495730 - 1092 WP_001205823.1 hypothetical protein -
JG530_RS17925 3495809..3496264 + 456 WP_000273724.1 hypothetical protein -
JG530_RS17930 3496471..3496896 - 426 WP_000693855.1 Rha family transcriptional regulator -
JG530_RS17935 3496880..3497152 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
JG530_RS17940 3497261..3497662 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JG530_RS17945 3497690..3497881 + 192 WP_000536233.1 hypothetical protein Antitoxin
JG530_RS17950 3497881..3498168 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG530_RS17955 3498446..3498601 + 156 WP_000379575.1 DUF1391 family protein -
JG530_RS17960 3498743..3499132 + 390 WP_000394511.1 hypothetical protein -
JG530_RS17965 3499319..3499504 - 186 WP_001133046.1 hypothetical protein -
JG530_RS17970 3500078..3500266 + 189 WP_000413705.1 cell division inhibition protein DicB -
JG530_RS17975 3500263..3500454 + 192 WP_001098307.1 DUF1482 family protein -
JG530_RS17980 3500548..3503019 + 2472 WP_199557128.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T184950 WP_001303876.1 NZ_CP066756:3497881-3498168 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T184950 NZ_CP087851:743377-743712 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT184950 WP_000536233.1 NZ_CP066756:3497690-3497881 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT184950 NZ_CP087851:743135-743377 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References