Detailed information of TA system TA184947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 2420015..2420486
• Replicon: chromosome
• Accession: NZ_CP066756
• Organism: Escherichia coli O157:H7 strain ECP19-798

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A0D7C2L1
• Locus tag: JG530_RS11980
• Protein ID: WP_001303511.1
• Coordinates: 2420015..2420293 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XAD5
• Locus tag: JG530_RS11985
• Protein ID: WP_001302048.1
• Coordinates: 2420295..2420486 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG530_RS11950	2415240..2415491	-	252	WP_000005552.1	excisionase family protein	-
JG530_RS11955	2415564..2418035	-	2472	WP_000048458.1	exonuclease	-
JG530_RS11960	2418128..2418319	-	192	WP_001090200.1	DUF1482 family protein	-
JG530_RS11965	2418316..2418504	-	189	WP_000449192.1	cell division inhibition protein DicB	-
JG530_RS11970	2419073..2419291	-	219	WP_001171930.1	hypothetical protein	-
JG530_RS11975	2419363..2419662	-	300	WP_001240334.1	hypothetical protein	-
JG530_RS11980	2420015..2420293	-	279	WP_001303511.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JG530_RS11985	2420295..2420486	-	192	WP_001302048.1	hypothetical protein	Antitoxin
JG530_RS11990	2420507..2420878	-	372	WP_001169686.1	hypothetical protein	-
JG530_RS11995	2420976..2421278	+	303	WP_000172738.1	transcriptional regulator	-
JG530_RS12000	2421275..2421700	+	426	WP_000693943.1	Rha family transcriptional regulator	-
JG530_RS12005	2421723..2422685	+	963	WP_000095669.1	helix-turn-helix domain-containing protein	-
JG530_RS12010	2422692..2423432	+	741	WP_000788938.1	ATP-binding protein	-
JG530_RS12015	2423458..2424227	+	770	Protein_2350	DUF1627 domain-containing protein	-
JG530_RS12020	2424243..2424638	+	396	WP_001118159.1	DUF977 family protein	-
JG530_RS12025	2424695..2425279	+	585	WP_000206793.1	DUF551 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleG7'	2411728..2461786	50058

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10661.25 Da
• Isoelectric Point: 5.5647

>T184947 WP_001303511.1 NZ_CP066756:c2420293-2420015 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Nucleotide

• Length: 279 bp

>T184947 NZ_CP087848:c2205391-2205203 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7463.47 Da
• Isoelectric Point: 8.6828

>AT184947 WP_001302048.1 NZ_CP066756:c2420486-2420295 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Nucleotide

• Length: 192 bp

>AT184947 NZ_CP087848:c2205140-2204733 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Structures

Toxin

• PDB: 5CZF
• PDB: 5CW7
• PDB: 5CZE

Antitoxin

• PDB: 5CZF
• PDB: 3ZBE
• PDB: 5CW7
• AlphaFold DB: A0A829CTP0