Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3567148..3567626 Replicon chromosome
Accession NZ_CP066753
Organism Escherichia coli O157:H7 strain ECP19-598

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JG531_RS18340 Protein ID WP_001303876.1
Coordinates 3567339..3567626 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JG531_RS18335 Protein ID WP_000536233.1
Coordinates 3567148..3567339 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG531_RS18300 3562552..3563322 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JG531_RS18305 3563344..3564090 - 747 WP_000788751.1 ATP-binding protein -
JG531_RS18310 3564097..3565188 - 1092 WP_001205823.1 hypothetical protein -
JG531_RS18315 3565267..3565722 + 456 WP_000273724.1 hypothetical protein -
JG531_RS18320 3565929..3566354 - 426 WP_000693855.1 Rha family transcriptional regulator -
JG531_RS18325 3566338..3566610 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
JG531_RS18330 3566719..3567120 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JG531_RS18335 3567148..3567339 + 192 WP_000536233.1 hypothetical protein Antitoxin
JG531_RS18340 3567339..3567626 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG531_RS18345 3567904..3568059 + 156 WP_000379575.1 DUF1391 family protein -
JG531_RS18350 3568201..3568590 + 390 WP_000394511.1 hypothetical protein -
JG531_RS18355 3568777..3568962 - 186 WP_001133046.1 hypothetical protein -
JG531_RS18360 3569536..3569724 + 189 WP_000413705.1 cell division inhibition protein DicB -
JG531_RS18365 3569721..3569912 + 192 WP_001098307.1 DUF1482 family protein -
JG531_RS18370 3570006..3572476 + 2471 Protein_3594 3'-5' exoribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T184914 WP_001303876.1 NZ_CP066753:3567339-3567626 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T184914 NZ_CP087843:313803-314138 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT184914 WP_000536233.1 NZ_CP066753:3567148-3567339 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT184914 NZ_CP087843:314128-314409 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References