Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3453340..3453818 Replicon chromosome
Accession NZ_CP066748
Organism Escherichia coli O157:H7 strain ECP19-2498

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag JG532_RS17825 Protein ID WP_001303876.1
Coordinates 3453531..3453818 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag JG532_RS17820 Protein ID WP_000536233.1
Coordinates 3453340..3453531 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG532_RS17785 3448744..3449514 - 771 WP_000450992.1 DUF1627 domain-containing protein -
JG532_RS17790 3449536..3450282 - 747 WP_000788751.1 ATP-binding protein -
JG532_RS17795 3450289..3451380 - 1092 WP_001205823.1 hypothetical protein -
JG532_RS17800 3451459..3451914 + 456 WP_000273724.1 hypothetical protein -
JG532_RS17805 3452121..3452546 - 426 WP_000693855.1 Rha family transcriptional regulator -
JG532_RS17810 3452530..3452802 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
JG532_RS17815 3452911..3453312 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
JG532_RS17820 3453340..3453531 + 192 WP_000536233.1 hypothetical protein Antitoxin
JG532_RS17825 3453531..3453818 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JG532_RS17830 3454096..3454251 + 156 WP_000379575.1 DUF1391 family protein -
JG532_RS17835 3454393..3454782 + 390 WP_000394511.1 hypothetical protein -
JG532_RS17840 3454969..3455154 - 186 WP_001133046.1 hypothetical protein -
JG532_RS17845 3455728..3455916 + 189 WP_000413705.1 cell division inhibition protein DicB -
JG532_RS17850 3455913..3456104 + 192 WP_001098307.1 DUF1482 family protein -
JG532_RS17855 3456198..3458669 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T184873 WP_001303876.1 NZ_CP066748:3453531-3453818 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T184873 NZ_CP087828:1781180-1781458 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT184873 WP_000536233.1 NZ_CP066748:3453340-3453531 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT184873 NZ_CP087828:1781445-1781732 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References