Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2565898..2566369 | Replicon | chromosome |
| Accession | NZ_CP066748 | ||
| Organism | Escherichia coli O157:H7 strain ECP19-2498 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | JG532_RS12995 | Protein ID | WP_001303511.1 |
| Coordinates | 2565898..2566176 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | JG532_RS13000 | Protein ID | WP_001302048.1 |
| Coordinates | 2566178..2566369 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JG532_RS12960 | 2560904..2561088 | - | 185 | Protein_2536 | DUF3596 domain-containing protein | - |
| JG532_RS12965 | 2561123..2561374 | - | 252 | WP_000005552.1 | excisionase family protein | - |
| JG532_RS12970 | 2561447..2563918 | - | 2472 | WP_000048458.1 | exonuclease | - |
| JG532_RS12975 | 2564011..2564202 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| JG532_RS12980 | 2564199..2564387 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| JG532_RS12985 | 2564956..2565174 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| JG532_RS12990 | 2565246..2565545 | - | 300 | WP_001240334.1 | hypothetical protein | - |
| JG532_RS12995 | 2565898..2566176 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JG532_RS13000 | 2566178..2566369 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| JG532_RS13005 | 2566390..2566761 | - | 372 | WP_001169686.1 | hypothetical protein | - |
| JG532_RS13010 | 2566859..2567161 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| JG532_RS13015 | 2567158..2567583 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| JG532_RS13020 | 2567606..2568568 | + | 963 | WP_000095670.1 | helix-turn-helix domain-containing protein | - |
| JG532_RS13025 | 2568575..2569315 | + | 741 | WP_000788936.1 | ATP-binding protein | - |
| JG532_RS13030 | 2569341..2570110 | + | 770 | Protein_2550 | DUF1627 domain-containing protein | - |
| JG532_RS13035 | 2570126..2570521 | + | 396 | WP_001118159.1 | DUF977 family protein | - |
| JG532_RS13040 | 2570578..2571162 | + | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleA/espI | 2545890..2607596 | 61706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T184867 WP_001303511.1 NZ_CP066748:c2566176-2565898 [Escherichia coli O157:H7]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T184867 NZ_CP087825:2776039-2776431 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTTTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTTTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT184867 WP_001302048.1 NZ_CP066748:c2566369-2566178 [Escherichia coli O157:H7]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT184867 NZ_CP087825:2775779-2776042 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|