Detailed information of TA system TA184849

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 12410..13328
• Replicon: plasmid unnamed
• Accession: NZ_CP066747
• Organism: Campylobacter jejuni strain CJP19-D445 isolate CFSAN091031

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: JG535_RS08715
• Protein ID: WP_002907829.1
• Coordinates: 12645..13328 (+)
• Length: 228 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A3Z9GMV3
• Locus tag: JG535_RS08710
• Protein ID: WP_002907823.1
• Coordinates: 12410..12652 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG535_RS08695	7549..9762	+	2214	WP_002907814.1	DUF1738 domain-containing protein	-
JG535_RS08700	9759..11582	+	1824	WP_002907817.1	type IV secretory system conjugative DNA transfer family protein	-
JG535_RS08705	11599..12318	+	720	WP_002907820.1	conjugal transfer protein TraL	-
JG535_RS08710	12410..12652	+	243	WP_002907823.1	hypothetical protein	Antitoxin
JG535_RS08715	12645..13328	+	684	WP_002907829.1	Fic family protein	Toxin
JG535_RS08720	13333..13800	+	468	WP_002907837.1	signal peptidase I	-
JG535_RS08725	13889..14296	+	408	WP_002907839.1	hypothetical protein	-
JG535_RS08730	14306..14629	+	324	WP_002907841.1	hypothetical protein	-
JG535_RS08735	14626..15021	+	396	WP_002907843.1	hypothetical protein	-
JG535_RS08740	15018..15521	+	504	WP_002907844.1	hypothetical protein	-
JG535_RS08745	15518..16060	+	543	WP_002907846.1	hypothetical protein	-
JG535_RS08750	16061..16456	+	396	WP_002907857.1	conjugal transfer protein TraM	-
JG535_RS08755	16537..17223	+	687	WP_002907859.1	AAA family ATPase	-
JG535_RS08760	17226..17450	+	225	WP_002907861.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..28218	28218

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 228 a.a.
• Molecular weight: 26164.33 Da
• Isoelectric Point: 10.0750

>T184849 WP_002907829.1 NZ_CP066747:12645-13328 [Campylobacter jejuni]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLISKHKMIYACAEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGISL

Nucleotide

• Length: 684 bp

>T184849 NZ_CP087823:c1016530-1016252 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9276.49 Da
• Isoelectric Point: 4.3697

>AT184849 WP_002907823.1 NZ_CP066747:12410-12652 [Campylobacter jejuni]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEGIKSVICGHAIEDMFANEKDVIDMIKIAKDEANADEIIAEYKREWGVND

Nucleotide

• Length: 243 bp

>AT184849 NZ_CP087823:c1016237-1015932 [Moraxella bovis]
ATGTTCAAAAATGGCATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGC
CACCGCCTTAGCAAATGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGC
CTTGCCGAAACTACGCTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A3Z9GMV3