Detailed information of TA system TA184848

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1700641..1701122
• Replicon: chromosome
• Accession: NZ_CP066739
• Organism: Histophilus somni strain ASc-MMNZ-VFA-069

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JFJ84_RS08030
• Protein ID: WP_041604052.1
• Coordinates: 1700862..1701122 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JFJ84_RS08025
• Protein ID: WP_011608602.1
• Coordinates: 1700641..1700862 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFJ84_RS08020	1698289..1700205	-	1917	Protein_1551	transferrin-binding protein-like solute binding protein	-
JFJ84_RS08025	1700641..1700862	+	222	WP_011608602.1	hypothetical protein	Antitoxin
JFJ84_RS08030	1700862..1701122	+	261	WP_041604052.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JFJ84_RS08035	1701301..1701855	-	555	WP_081376844.1	DUF560 domain-containing protein	-
JFJ84_RS08040	1701786..1702757	-	972	WP_081376843.1	DUF560 domain-containing protein	-
JFJ84_RS08045	1703243..1703662	-	420	WP_075290581.1	pseudouridine synthase	-
JFJ84_RS08050	1703728..1705068	-	1341	WP_075290583.1	PTS sugar transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-70)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10040.80 Da
• Isoelectric Point: 10.2656

>T184848 WP_041604052.1 NZ_CP066739:1700862-1701122 [Histophilus somni]
MYTLRYSDKALKQLCKLDKGIQKLILTWIANNLENCENPRIKGKGLTGNRSGEWRYRVGDYRIICDIRDSKLIILALSIG
HRKNIY

Nucleotide

• Length: 261 bp

>T184848 NZ_CP087823:833356-833691 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8515.60 Da
• Isoelectric Point: 4.4142

>AT184848 WP_011608602.1 NZ_CP066739:1700641-1700862 [Histophilus somni]
MAISVRLNAQDEQLFKSYAKTNNITLSELFRNAVFEKIEDEYDLAVYRESLEDYNKTPMSYSHAEVCKMLGIE

Nucleotide

• Length: 222 bp

>AT184848 NZ_CP087823:833114-833356 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA