Detailed information of TA system TA184847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1014105..1014663
• Replicon: chromosome
• Accession: NZ_CP066739
• Organism: Histophilus somni strain ASc-MMNZ-VFA-069

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UUG7
• Locus tag: JFJ84_RS05015
• Protein ID: WP_012340589.1
• Coordinates: 1014105..1014377 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UUG6
• Locus tag: JFJ84_RS05020
• Protein ID: WP_012340588.1
• Coordinates: 1014370..1014663 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFJ84_RS04980	1009247..1009531	+	285	WP_011609129.1	integration host factor subunit beta	-
JFJ84_RS04985	1009651..1009935	+	285	WP_012340596.1	DUF1049 domain-containing protein	-
JFJ84_RS04990	1009945..1011141	+	1197	WP_012340595.1	lipopolysaccharide assembly protein LapB	-
JFJ84_RS04995	1011165..1011671	-	507	WP_012340594.1	GNAT family N-acetyltransferase	-
JFJ84_RS05000	1011661..1011960	-	300	WP_012340592.1	DUF1778 domain-containing protein	-
JFJ84_RS05005	1012159..1012440	-	282	WP_012340591.1	virulence factor	-
JFJ84_RS05010	1012878..1014020	+	1143	WP_075290626.1	porin	-
JFJ84_RS05015	1014105..1014377	-	273	WP_012340589.1	type II toxin-antitoxin system YafQ family toxin	Toxin
JFJ84_RS05020	1014370..1014663	-	294	WP_012340588.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JFJ84_RS05025	1015084..1015503	-	420	WP_199275234.1	SufE family protein	-
JFJ84_RS05030	1015500..1016699	-	1200	WP_012340584.1	cysteine desulfurase	-
JFJ84_RS05035	1016689..1017192	-	504	WP_012340583.1	thermonuclease family protein	-
JFJ84_RS05040	1017314..1017730	+	417	WP_075293924.1	CidA/LrgA family protein	-
JFJ84_RS05045	1017727..1018416	+	690	WP_199275235.1	CidB/LrgB family autolysis modulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-72)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10472.11 Da
• Isoelectric Point: 6.9669

>T184847 WP_012340589.1 NZ_CP066739:c1014377-1014105 [Histophilus somni]
MAKRKFDMAKSFKRDLRKHYLALVGEAWAEISNCLLNDLPIPEKYQDHPLKGDKSGFRDCHVKPDLVLIYKIVDDVVELH
YLDSHSEIFG

Nucleotide

• Length: 273 bp

>T184847 NZ_CP087823:729378-729779 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTACATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCGTACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11279.60 Da
• Isoelectric Point: 4.7815

>AT184847 WP_012340588.1 NZ_CP066739:c1014663-1014370 [Histophilus somni]
MDYTNFNMRLDNDLRGRAYPILEQYGLTPSQAVRMFFNQIAQTGKIPLSFDWAENQTLTPKAAARLRQTEQEFANGEFER
FYSLDELNQAIKEISHG

Nucleotide

• Length: 294 bp

>AT184847 NZ_CP087823:729130-729363 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA

Structures

Toxin

• AlphaFold DB: B0UUG7

Antitoxin

• AlphaFold DB: B0UUG6