Detailed information of TA system TA184846

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 826557..827156
• Replicon: chromosome
• Accession: NZ_CP066739
• Organism: Histophilus somni strain ASc-MMNZ-VFA-069

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: JFJ84_RS04225
• Protein ID: WP_012340732.1
• Coordinates: 826851..827156 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UV75
• Locus tag: JFJ84_RS04220
• Protein ID: WP_012340733.1
• Coordinates: 826557..826847 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JFJ84_RS04190	822400..822861	-	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-
JFJ84_RS04195	823050..823502	-	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
JFJ84_RS04200	823785..824705	+	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
JFJ84_RS04205	824752..825195	+	444	WP_012340735.1	NfeD family protein	-
JFJ84_RS04210	825205..825825	+	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
JFJ84_RS04215	825822..826385	+	564	WP_178384292.1	molecular chaperone	-
JFJ84_RS04220	826557..826847	+	291	WP_012340733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JFJ84_RS04225	826851..827156	+	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
JFJ84_RS04230	827377..827613	+	237	WP_080514392.1	recombinase family protein	-
JFJ84_RS04235	827597..828718	-	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
JFJ84_RS04240	828859..830910	+	2052	WP_012340730.1	methionine--tRNA ligase	-
JFJ84_RS04245	830946..831806	-	861	WP_011609333.1	RNase adapter RapZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T184846 WP_012340732.1 NZ_CP066739:826851-827156 [Histophilus somni]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T184846 NZ_CP087823:568734-568922 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10804.13 Da
• Isoelectric Point: 4.2845

>AT184846 WP_012340733.1 NZ_CP066739:826557-826847 [Histophilus somni]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT184846 NZ_CP087823:568985-569392 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Structures

Toxin

• AlphaFold DB: B0UV74

Antitoxin

• AlphaFold DB: B0UV75