Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 461699..462431 Replicon chromosome
Accession NZ_CP066739
Organism Histophilus somni strain ASc-MMNZ-VFA-069

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag JFJ84_RS02385 Protein ID WP_075294106.1
Coordinates 461964..462431 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag JFJ84_RS02380 Protein ID WP_011609927.1
Coordinates 461699..461962 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JFJ84_RS02355 456806..457168 + 363 WP_199275185.1 hypothetical protein -
JFJ84_RS02360 457232..459520 + 2289 WP_199275186.1 hypothetical protein -
JFJ84_RS02365 460186..460842 + 657 WP_199275187.1 hypothetical protein -
JFJ84_RS02370 460996..461250 + 255 WP_075294108.1 DUF1778 domain-containing protein -
JFJ84_RS02375 461250..461561 + 312 WP_198974122.1 hypothetical protein -
JFJ84_RS02380 461699..461962 + 264 WP_011609927.1 DUF1778 domain-containing protein Antitoxin
JFJ84_RS02385 461964..462431 + 468 WP_075294106.1 GNAT family N-acetyltransferase Toxin
JFJ84_RS02390 463110..463412 - 303 WP_075294105.1 DUF2442 domain-containing protein -
JFJ84_RS02395 463381..463635 - 255 WP_075294104.1 DUF4160 domain-containing protein -
JFJ84_RS02400 463767..464027 - 261 Protein_463 hemophilus-specific protein -
JFJ84_RS02405 464104..464520 - 417 WP_198974231.1 IS200/IS605 family transposase -
JFJ84_RS02410 464567..465703 + 1137 WP_199275188.1 transposase -
JFJ84_RS02415 465960..466889 + 930 WP_075293400.1 hypothetical protein -
JFJ84_RS02420 466908..467354 - 447 WP_075293401.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 464104..464520 416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17344.33 Da        Isoelectric Point: 10.5585

>T184845 WP_075294106.1 NZ_CP066739:461964-462431 [Histophilus somni]
MYSAPELLTHHHHLGAFNCGEESLNIWLKRHALRNRQNRASRTFVICNENVVVGFYALAAGSVTHRFVSGALRRNMPEPI
PVVVLGRLAIDIKHQGKKLGAALLKDVVLRARAVSEQVGVRALLVHALNDKAKQFYLNYGFQPSPIDDMLLMLKL

Download         Length: 468 bp

>T184845 NZ_CP087821:c2392782-2392480 [Moraxella bovis]
ATGACCAAGTCTGATAAATTAAAAGCCAAATTGTATGGCGATGTACGAACTTTTGTATTTAGTGATTTGGTTACTTTATT
ATCGCAATTAGGTTATGAAATGCACGAACGGGCAGGTTCTCGTGTGGTATTTGTTCATTGTGATGATAATAGCGACCGCA
TTCATTTGCATAAACCCCACCCCGAAAATACCATTAAAGGTGGAGCATTAAAAGCGGTCAAAGCCTATTTGTCCGAAAAA
GGCTATTTTGATGAATTTAATGATGATGTGTTAAATCAGGAGCTTAAAAATGATGACCTATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9906.35 Da        Isoelectric Point: 5.6388

>AT184845 WP_011609927.1 NZ_CP066739:461699-461962 [Histophilus somni]
MRTAAINLRVQPKQRDLIDYAASLLGKTRSDFMLDVACTYAQNVILDRTVFQLDEGKFNHFIEVLEQPNLPNAGLEKLMA
THSPWES

Download         Length: 264 bp

>AT184845 NZ_CP087821:c2392493-2392158 [Moraxella bovis]
ATGATGACCTATAAAGGCTATGTTGGCGAATTTACGCTTGATAATGATGATGAAATATTTTATGGTAAACTTATTGGCAT
TAATCAGCTTGTTACTTTTGAAGCAGACAATGCCCATGATTTAAAACAAGCCTTTTATGACAGCGTGGACGATTATTTGG
CGTTTTGTGCTGAACAAGGCATAGAGCCTGATAAGCCTTTTAAGGGTTCATTTAATGTGCGTATTGATAGCGAATTGCAC
CGCCGTGCTTATATGGCAAGCCGTGACAGTAGTTTAAATGCGTTTGTAGGACAAGCCATTAGTGAAAAGCTAAATAGAAT
GGCTGTATCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References