Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 941538..942067 Replicon chromosome
Accession NZ_CP066726
Organism Staphylococcus xylosus strain TMW 2.1324

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4NYG1
Locus tag JGY90_RS04410 Protein ID WP_047172098.1
Coordinates 941705..942067 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D4YKY9
Locus tag JGY90_RS04405 Protein ID WP_017722121.1
Coordinates 941538..941708 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY90_RS04380 (JGY90_04355) 937315..937794 + 480 WP_047172094.1 PH domain-containing protein -
JGY90_RS04385 (JGY90_04360) 937787..939295 + 1509 WP_047172095.1 PH domain-containing protein -
JGY90_RS04390 (JGY90_04365) 939282..939773 + 492 WP_047172096.1 PH domain-containing protein -
JGY90_RS04395 (JGY90_04370) 939835..940188 + 354 WP_042362337.1 holo-ACP synthase -
JGY90_RS04400 (JGY90_04375) 940302..941450 + 1149 WP_107545718.1 alanine racemase -
JGY90_RS04405 (JGY90_04380) 941538..941708 + 171 WP_017722121.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JGY90_RS04410 (JGY90_04385) 941705..942067 + 363 WP_047172098.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGY90_RS04415 (JGY90_04390) 942416..943417 + 1002 WP_047172099.1 PP2C family protein-serine/threonine phosphatase -
JGY90_RS04420 (JGY90_04395) 943497..943823 + 327 WP_029377954.1 anti-sigma factor antagonist -
JGY90_RS04425 (JGY90_04400) 943825..944307 + 483 WP_029377953.1 anti-sigma B factor RsbW -
JGY90_RS04430 (JGY90_04405) 944282..945052 + 771 WP_047172100.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13551.81 Da        Isoelectric Point: 10.3173

>T184838 WP_047172098.1 NZ_CP066726:941705-942067 [Staphylococcus xylosus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEKKMKEVNIAIDISLGLHNIRNHKS

Download         Length: 363 bp

>T184838 NZ_CP087821:360180-360572 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTCTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT184838 WP_017722121.1 NZ_CP066726:941538-941708 [Staphylococcus xylosus]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT184838 NZ_CP087821:359920-360183 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4NYG1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D4YKY9

References