Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 929913..930421 Replicon chromosome
Accession NZ_CP066726
Organism Staphylococcus xylosus strain TMW 2.1324

Toxin (Protein)


Gene name TsdT Uniprot ID A0A5R9B1P1
Locus tag JGY90_RS04350 Protein ID WP_042362331.1
Coordinates 930221..930421 (+) Length 67 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A418I4X8
Locus tag JGY90_RS04345 Protein ID WP_029377967.1
Coordinates 929913..930206 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY90_RS04320 (JGY90_04295) 925029..925817 + 789 WP_047172092.1 hydroxyethylthiazole kinase -
JGY90_RS04325 (JGY90_04300) 925820..926458 + 639 WP_047172093.1 thiamine phosphate synthase -
JGY90_RS04330 (JGY90_04305) 926546..927415 + 870 WP_029377970.1 membrane protein insertase YidC -
JGY90_RS04335 (JGY90_04310) 927527..928135 - 609 WP_171031846.1 HD domain-containing protein -
JGY90_RS04340 (JGY90_04315) 928286..929770 - 1485 WP_042362330.1 cardiolipin synthase -
JGY90_RS04345 (JGY90_04320) 929913..930206 + 294 WP_029377967.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGY90_RS04350 (JGY90_04325) 930221..930421 + 201 WP_042362331.1 heavy metal-associated domain-containing protein Toxin
JGY90_RS04355 (JGY90_04330) 930637..930777 + 141 WP_099265859.1 Lmo0850 family protein -
JGY90_RS04360 (JGY90_04335) 931121..932326 - 1206 WP_042362332.1 FtsW/RodA/SpoVE family cell cycle protein -
JGY90_RS04365 (JGY90_04340) 932578..933648 + 1071 WP_038678888.1 D-alanine--D-alanine ligase -
JGY90_RS04370 (JGY90_04345) 933661..935016 + 1356 WP_042362333.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-64)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 67 a.a.        Molecular weight: 7517.53 Da        Isoelectric Point: 4.5845

>T184837 WP_042362331.1 NZ_CP066726:930221-930421 [Staphylococcus xylosus]
VQSKVIYVSGINSERQYQIKQRLMNVIGVHSVAIDSDKGEILVDFETPASLNNLEKEIYDLGYQIF

Download         Length: 201 bp

>T184837 NZ_CP087821:357086-357358 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11195.85 Da        Isoelectric Point: 6.8624

>AT184837 WP_029377967.1 NZ_CP066726:929913-930206 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT184837 NZ_CP087821:356800-357093 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGACTAGACAACGACCTACGCCAAAAAGTCTATCCTGTGCTAGAACAATACGGCTT
GACCCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9B1P1

Antitoxin

Source ID Structure
AlphaFold DB A0A418I4X8

References