Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1993007..1993815 Replicon chromosome
Accession NZ_CP066721
Organism Staphylococcus xylosus strain 2.1523

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JGY88_RS09620 Protein ID WP_225486523.1
Coordinates 1993351..1993815 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JGY88_RS09615 Protein ID WP_225486521.1
Coordinates 1993007..1993339 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY88_RS09570 (1988411) 1988411..1989166 - 756 WP_225486511.1 DnaD domain protein -
JGY88_RS09575 (1989153) 1989153..1989830 - 678 WP_225486512.1 putative HNHc nuclease -
JGY88_RS09580 (1989842) 1989842..1990291 - 450 WP_225486513.1 single-stranded DNA-binding protein -
JGY88_RS09585 (1990291) 1990291..1990911 - 621 WP_225486515.1 DUF1071 domain-containing protein -
JGY88_RS09590 (1990904) 1990904..1991164 - 261 WP_225486516.1 hypothetical protein -
JGY88_RS09595 (1991228) 1991228..1991407 - 180 WP_225486517.1 hypothetical protein -
JGY88_RS09600 (1991420) 1991420..1991704 - 285 WP_225486518.1 DUF771 domain-containing protein -
JGY88_RS09605 (1991716) 1991716..1992456 - 741 WP_225486519.1 phage antirepressor KilAC domain-containing protein -
JGY88_RS09610 (1992611) 1992611..1992841 - 231 WP_225486520.1 helix-turn-helix transcriptional regulator -
JGY88_RS09615 (1993007) 1993007..1993339 + 333 WP_225486521.1 helix-turn-helix transcriptional regulator Antitoxin
JGY88_RS09620 (1993351) 1993351..1993815 + 465 WP_225486523.1 ImmA/IrrE family metallo-endopeptidase Toxin
JGY88_RS09625 (1993902) 1993902..1994453 + 552 WP_225486524.1 Ltp family lipoprotein -
JGY88_RS09630 (1994517) 1994517..1994975 + 459 WP_225486525.1 hypothetical protein -
JGY88_RS09635 (1995032) 1995032..1996063 + 1032 WP_225486526.1 site-specific integrase -
JGY88_RS09650 (1996555) 1996555..1997118 - 564 WP_017722273.1 competence protein ComK -
JGY88_RS09655 (1997371) 1997371..1997589 + 219 WP_029379123.1 IDEAL domain-containing protein -
JGY88_RS09660 (1997689) 1997689..1998675 - 987 WP_047172628.1 lipoate--protein ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1952776..1996063 43287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(31-122)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-61)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18373.98 Da        Isoelectric Point: 5.0882

>T184832 WP_225486523.1 NZ_CP066721:1993351-1993815 [Staphylococcus xylosus]
MRNYENLLAEYDDEIIIEETNLKRGLAGLYLGEIILIEKRMNSVNKLETLYEEIGHHLVTYGDIRDQSKMLNRKFELKAR
RLGSELAISLDGIIDAFYHGVHNLFEMSEYFNVSEEYVLNTLKHYKMKYGLDVYYKGYVIKFEPLQVFEHYNWE

Download         Length: 465 bp

>T184832 NZ_CP087817:2074384-2074719 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12747.51 Da        Isoelectric Point: 6.7311

>AT184832 WP_225486521.1 NZ_CP066721:1993007-1993339 [Staphylococcus xylosus]
MFSQNLKYLRNKHNMEQIDLAHKLGRKSASSISEWEKGKYTPKMKTLLEIASIFNVNIDDLMGDDLATPKKENPKSSFET
IAAHLDGDLTEEEWQEILDYAEFVKSKRKK

Download         Length: 333 bp

>AT184832 NZ_CP087817:2074709-2074990 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References