Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 967638..968167 Replicon chromosome
Accession NZ_CP066721
Organism Staphylococcus xylosus strain 2.1523

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4NYG1
Locus tag JGY88_RS04530 Protein ID WP_047172098.1
Coordinates 967805..968167 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1D4YKY9
Locus tag JGY88_RS04525 Protein ID WP_017722121.1
Coordinates 967638..967808 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGY88_RS04500 (963415) 963415..963894 + 480 WP_101105572.1 PH domain-containing protein -
JGY88_RS04505 (963887) 963887..965395 + 1509 WP_225486824.1 PH domain-containing protein -
JGY88_RS04510 (965382) 965382..965873 + 492 WP_225486825.1 PH domain-containing protein -
JGY88_RS04515 (965935) 965935..966288 + 354 WP_101105575.1 holo-ACP synthase -
JGY88_RS04520 (966402) 966402..967550 + 1149 WP_101105576.1 alanine racemase -
JGY88_RS04525 (967638) 967638..967808 + 171 WP_017722121.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JGY88_RS04530 (967805) 967805..968167 + 363 WP_047172098.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGY88_RS04535 (968517) 968517..969518 + 1002 WP_225486826.1 PP2C family protein-serine/threonine phosphatase -
JGY88_RS04540 (969598) 969598..969924 + 327 WP_029377954.1 anti-sigma factor antagonist -
JGY88_RS04545 (969926) 969926..970408 + 483 WP_101105578.1 anti-sigma B factor RsbW -
JGY88_RS04550 (970383) 970383..971153 + 771 WP_225486827.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13551.81 Da        Isoelectric Point: 10.3173

>T184826 WP_047172098.1 NZ_CP066721:967805-968167 [Staphylococcus xylosus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSEKKMKEVNIAIDISLGLHNIRNHKS

Download         Length: 363 bp

>T184826 NZ_CP087817:c29721-29533 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6305.92 Da        Isoelectric Point: 4.0121

>AT184826 WP_017722121.1 NZ_CP066721:967638-967808 [Staphylococcus xylosus]
MASFNQSRNHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT184826 NZ_CP087817:c29470-29063 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4NYG1

Antitoxin

Source ID Structure
AlphaFold DB A0A1D4YKY9

References