Detailed information of TA system TA184825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 956072..956580
• Replicon: chromosome
• Accession: NZ_CP066721
• Organism: Staphylococcus xylosus strain 2.1523

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: JGY88_RS04470
• Protein ID: WP_225486934.1
• Coordinates: 956380..956580 (+)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A418I4X8
• Locus tag: JGY88_RS04465
• Protein ID: WP_029377967.1
• Coordinates: 956072..956365 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGY88_RS04440 (951182)	951182..951970	+	789	WP_101105562.1	hydroxyethylthiazole kinase	-
JGY88_RS04445 (951973)	951973..952611	+	639	WP_101105563.1	thiamine phosphate synthase	-
JGY88_RS04450 (952699)	952699..953568	+	870	WP_101105564.1	membrane protein insertase YidC	-
JGY88_RS04455 (953685)	953685..954293	-	609	WP_182477568.1	HD domain-containing protein	-
JGY88_RS04460 (954445)	954445..955929	-	1485	WP_119555453.1	cardiolipin synthase	-
JGY88_RS04465 (956072)	956072..956365	+	294	WP_029377967.1	copper-sensing transcriptional repressor CsoR	Antitoxin
JGY88_RS04470 (956380)	956380..956580	+	201	WP_225486934.1	heavy metal-associated domain-containing protein	Toxin
JGY88_RS04475 (956796)	956796..956936	+	141	WP_099265859.1	Lmo0850 family protein	-
JGY88_RS04480 (957220)	957220..958425	-	1206	WP_225486820.1	FtsW/RodA/SpoVE family cell cycle protein	-
JGY88_RS04485 (958677)	958677..959747	+	1071	WP_225486821.1	D-alanine--D-alanine ligase	-
JGY88_RS04490 (959760)	959760..961115	+	1356	WP_225486822.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-64)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7558.59 Da
• Isoelectric Point: 4.5845

>T184825 WP_225486934.1 NZ_CP066721:956380-956580 [Staphylococcus xylosus]
VQSKIIYVSGINSERQYQIKQRLMNVIGVHNVAIDSDKGEILVDFETPASLNNLEKEIYDLGYQIF

Nucleotide

• Length: 201 bp

>T184825 NZ_CP087814:2712705-2713040 [Moraxella bovis]
ATGTTGCATTTTGCTGAAACATCATTATTCACTAAACAAATCATAGACTTAATGGATGATGACGAGTACAGACTATTACA
AACAAACTTGATGAAAAACCCACATCAAGGCGACATTGTTCGTGGTACTGGCGGAGTACGCAAAACAAGATGGTCAATTG
ATGGCAAGGGCAAAAGTGGTGGCAGTCGCATCATTTACTTTTTTGTTGATGGTGCTGGCATTTTCTTTATGCTCTTGGCT
TATCCTAAATCAAAACAAACAACGCTATCGGCGGATGAGAAAAAAGAAATGCTCAAACTAACCACCGCAATTAAGGAGAT
TTACCGTGCAAAATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.85 Da
• Isoelectric Point: 6.8624

>AT184825 WP_029377967.1 NZ_CP066721:956072-956365 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT184825 NZ_CP087814:2713030-2713311 [Moraxella bovis]
GTGCAAAATGAGTTTTACGATGATTTAAAAGCCTCATTGACTGAGGCTCTGGCAATCGCTAAGGGCGAAATTTCCCCAAG
TCGTACATTCACTTATGAACGCCCAAACATCAAAGATATTCGGGCAAAAACAGGGCTATCACAAACCCAGTTCGCCCAGA
AGCTACACATAAGCCCTAAAACGCTTAAAAACTGGGAACAGGGCATTAGAACGCCAACAGGTCCAGCCATTACCCTAATT
AGATTACTTGACAAAAACCCTGATTTAATTAGCATGGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A418I4X8