Detailed information of TA system TA184820

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 952975..953483
• Replicon: chromosome
• Accession: NZ_CP066719
• Organism: Staphylococcus xylosus strain TMW 2.1602

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: JGY87_RS04420
• Protein ID: WP_029377966.1
• Coordinates: 953283..953483 (+)
• Length: 67 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A418I4X8
• Locus tag: JGY87_RS04415
• Protein ID: WP_029377967.1
• Coordinates: 952975..953268 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JGY87_RS04390 (JGY87_04355)	948085..948873	+	789	WP_038678895.1	hydroxyethylthiazole kinase	-
JGY87_RS04395 (JGY87_04360)	948876..949514	+	639	WP_037557147.1	thiamine phosphate synthase	-
JGY87_RS04400 (JGY87_04365)	949602..950471	+	870	WP_029377970.1	membrane protein insertase YidC	-
JGY87_RS04405 (JGY87_04370)	950588..951196	-	609	WP_051283164.1	HD domain-containing protein	-
JGY87_RS04410 (JGY87_04375)	951348..952832	-	1485	WP_029377968.1	cardiolipin synthase	-
JGY87_RS04415 (JGY87_04380)	952975..953268	+	294	WP_029377967.1	copper-sensing transcriptional repressor CsoR	Antitoxin
JGY87_RS04420 (JGY87_04385)	953283..953483	+	201	WP_029377966.1	heavy metal-associated domain-containing protein	Toxin
JGY87_RS04425 (JGY87_04390)	953698..953838	+	141	WP_099265859.1	Lmo0850 family protein	-
JGY87_RS04430 (JGY87_04395)	954118..955323	-	1206	WP_058625514.1	FtsW/RodA/SpoVE family cell cycle protein	-
JGY87_RS04435 (JGY87_04400)	955575..956645	+	1071	WP_038678888.1	D-alanine--D-alanine ligase	-
JGY87_RS04440 (JGY87_04405)	956658..958013	+	1356	WP_099265860.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (19-64)

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 67 a.a.
• Molecular weight: 7628.68 Da
• Isoelectric Point: 4.3997

>T184820 WP_029377966.1 NZ_CP066719:953283-953483 [Staphylococcus xylosus]
VQSKVIYVSDINSERQYQIKQRLMNVIGVHNVAIDIDKGEILVDFETPASLNNLEKEIYDLGYQIF

Nucleotide

• Length: 201 bp

>T184820 NZ_CP087814:1136110-1136367 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11195.85 Da
• Isoelectric Point: 6.8624

>AT184820 WP_029377967.1 NZ_CP066719:952975-953268 [Staphylococcus xylosus]
VTEIQKAHHSDQIKSNLKSRLNRIEGQVRAINRMVDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEKGQQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT184820 NZ_CP087814:1135878-1136120 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Structures

Antitoxin

• AlphaFold DB: A0A418I4X8