184819

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 905188..905712 Replicon chromosome
Accession NZ_CP066718
Organism Staphylococcus pseudintermedius strain DG064

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ36_RS04150 Protein ID WP_014613379.1
Coordinates 905359..905712 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ36_RS04145 Protein ID WP_014613378.1
Coordinates 905188..905358 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ36_RS04120 901077..901550 + 474 WP_037542551.1 PH domain-containing protein -
JGZ36_RS04125 901543..903072 + 1530 WP_037542554.1 PH domain-containing protein -
JGZ36_RS04130 903056..903574 + 519 WP_014613375.1 PH domain-containing protein -
JGZ36_RS04135 903571..903921 + 351 WP_037542556.1 holo-ACP synthase -
JGZ36_RS04140 903955..905103 + 1149 WP_014613377.1 alanine racemase -
JGZ36_RS04145 905188..905358 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ36_RS04150 905359..905712 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ36_RS04155 905770..906774 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JGZ36_RS04160 906853..907179 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ36_RS04165 907179..907658 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ36_RS04170 907633..908403 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184819 WP_014613379.1 NZ_CP066718:905359-905712 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184819 NZ_CP087814:1135878-1136120 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184819 WP_014613378.1 NZ_CP066718:905188-905358 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184819 NZ_CP087814:1136110-1136367 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References