Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 844079..844600 Replicon chromosome
Accession NZ_CP066717
Organism Staphylococcus pseudintermedius strain DG072

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ25_RS03715 Protein ID WP_014613364.1
Coordinates 844379..844600 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ25_RS03710 Protein ID WP_014613363.1
Coordinates 844079..844366 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ25_RS03685 839340..840143 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JGZ25_RS03690 840133..840771 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ25_RS03695 840860..841726 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ25_RS03700 841780..842436 - 657 WP_014613361.1 HD domain-containing protein -
JGZ25_RS03705 842457..843947 - 1491 WP_014613362.1 cardiolipin synthase -
JGZ25_RS03710 844079..844366 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ25_RS03715 844379..844600 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ25_RS03720 844604..844810 + 207 WP_014613365.1 cation transporter -
JGZ25_RS03725 844911..847091 + 2181 WP_037542539.1 heavy metal translocating P-type ATPase -
JGZ25_RS03730 847177..847323 + 147 WP_014613367.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184815 WP_014613364.1 NZ_CP066717:844379-844600 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184815 NZ_CP087814:639458-639859 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTACATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCGTACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184815 WP_014613363.1 NZ_CP066717:844079-844366 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184815 NZ_CP087814:639210-639443 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References