Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 856663..857187 Replicon chromosome
Accession NZ_CP066714
Organism Staphylococcus pseudintermedius strain DSP021

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ18_RS03800 Protein ID WP_014613379.1
Coordinates 856834..857187 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ18_RS03795 Protein ID WP_014613378.1
Coordinates 856663..856833 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ18_RS03770 852552..853025 + 474 WP_037542551.1 PH domain-containing protein -
JGZ18_RS03775 853018..854547 + 1530 WP_037542554.1 PH domain-containing protein -
JGZ18_RS03780 854531..855049 + 519 WP_014613375.1 PH domain-containing protein -
JGZ18_RS03785 855046..855396 + 351 WP_037542556.1 holo-ACP synthase -
JGZ18_RS03790 855430..856578 + 1149 WP_014613377.1 alanine racemase -
JGZ18_RS03795 856663..856833 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ18_RS03800 856834..857187 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ18_RS03805 857245..858249 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JGZ18_RS03810 858328..858654 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ18_RS03815 858654..859133 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ18_RS03820 859108..859878 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184810 WP_014613379.1 NZ_CP066714:856834-857187 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184810 NZ_CP087811:1794509-1794787 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184810 WP_014613378.1 NZ_CP066714:856663-856833 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184810 NZ_CP087811:1794802-1795107 [Moraxella bovis]
ATGTTCAAAAATGGCATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGC
CACCGCCTTAGCAAATGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGC
CTTGCCGAAACTACGCTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References