184800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 803411..803935 Replicon chromosome
Accession NZ_CP066712
Organism Staphylococcus pseudintermedius strain DSP027

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ40_RS03565 Protein ID WP_014613379.1
Coordinates 803582..803935 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ40_RS03560 Protein ID WP_014613378.1
Coordinates 803411..803581 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ40_RS03535 (JGZ40_03490) 799300..799773 + 474 WP_063279122.1 PH domain-containing protein -
JGZ40_RS03540 (JGZ40_03495) 799766..801295 + 1530 WP_063279121.1 PH domain-containing protein -
JGZ40_RS03545 (JGZ40_03500) 801279..801797 + 519 WP_014613375.1 PH domain-containing protein -
JGZ40_RS03550 (JGZ40_03505) 801794..802144 + 351 WP_063279120.1 holo-ACP synthase -
JGZ40_RS03555 (JGZ40_03510) 802178..803326 + 1149 WP_014613377.1 alanine racemase -
JGZ40_RS03560 (JGZ40_03515) 803411..803581 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JGZ40_RS03565 (JGZ40_03520) 803582..803935 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ40_RS03570 (JGZ40_03525) 803993..804997 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JGZ40_RS03575 (JGZ40_03530) 805076..805402 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ40_RS03580 (JGZ40_03535) 805402..805881 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ40_RS03585 (JGZ40_03540) 805856..806626 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184800 WP_014613379.1 NZ_CP066712:803582-803935 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184800 NZ_CP087806:2184066-2184338 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184800 WP_014613378.1 NZ_CP066712:803411-803581 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184800 NZ_CP087806:2183780-2184073 [Moraxella bovis]
ATGAGCCGCACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACCCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References