184798

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 824131..824655 Replicon chromosome
Accession NZ_CP066711
Organism Staphylococcus pseudintermedius strain DSP030

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ56_RS03630 Protein ID WP_014613379.1
Coordinates 824302..824655 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ56_RS03625 Protein ID WP_014613378.1
Coordinates 824131..824301 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ56_RS03600 820020..820493 + 474 WP_099997346.1 PH domain-containing protein -
JGZ56_RS03605 820486..822015 + 1530 WP_199274370.1 PH domain-containing protein -
JGZ56_RS03610 821999..822517 + 519 WP_014613375.1 PH domain-containing protein -
JGZ56_RS03615 822514..822864 + 351 WP_140240885.1 holo-ACP synthase -
JGZ56_RS03620 822898..824046 + 1149 WP_065354670.1 alanine racemase -
JGZ56_RS03625 824131..824301 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ56_RS03630 824302..824655 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ56_RS03635 824713..825717 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JGZ56_RS03640 825796..826122 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ56_RS03645 826122..826601 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ56_RS03650 826576..827346 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184798 WP_014613379.1 NZ_CP066711:824302-824655 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184798 NZ_CP087806:c1743170-1742979 [Moraxella bovis]
ATGGCAAGCAGTAGAGAAGTCATTAAAATCATAAAAGCTGACGGTTGGTATCGTGTTAAATCAAATGGCGGTAGTCATCA
GCAATTCAAACACCCCACCAAAAAAGGTCGAGTTACTGTTCCCCACCCCAAAAAAGACTTAGCACAACCCACCATTGACA
GCATTATGAGACAAGCAGGGCTAAGCGATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184798 WP_014613378.1 NZ_CP066711:824131-824301 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184798 NZ_CP087806:c1742945-1742541 [Moraxella bovis]
ATGTTATACCCCATTGCAATCTTAAAGGGCGATGATAAAACCGCCCACGGTATCTTTTTTCCCGATGTGCCAAATCTTGC
CAGTGCGTGCGATGACTTGCAAGACGTACACAAAATGGCACTAGAATGCCTTGATGTGCATTTTAGTGGCTTGGTAGAAG
ACGGCGAAGAAATCCCATTACCCACCAATTTTGACGCACACACCCAAAATAGCCAATTTGACGGCATGATGTGGGCGTGG
GTAGATGTGGACTTGTCAAAATATGACGTAAAAAGCCATAAAATCAACATTACCTTGCCTAACTATCTGATTGCCAAAAT
TGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATTTGG
GGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References