Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 809215..809736 Replicon chromosome
Accession NZ_CP066711
Organism Staphylococcus pseudintermedius strain DSP030

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ56_RS03555 Protein ID WP_014613364.1
Coordinates 809515..809736 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ56_RS03550 Protein ID WP_014613363.1
Coordinates 809215..809502 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ56_RS03525 804476..805279 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JGZ56_RS03530 805269..805907 + 639 WP_099997350.1 thiamine phosphate synthase -
JGZ56_RS03535 805996..806862 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ56_RS03540 806916..807572 - 657 WP_070407666.1 HD domain-containing protein -
JGZ56_RS03545 807593..809083 - 1491 WP_065520420.1 cardiolipin synthase -
JGZ56_RS03550 809215..809502 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ56_RS03555 809515..809736 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ56_RS03560 809740..809946 + 207 WP_014613365.1 cation transporter -
JGZ56_RS03565 810047..812227 + 2181 WP_199274369.1 heavy metal translocating P-type ATPase -
JGZ56_RS03570 812313..812459 + 147 WP_014613367.1 hypothetical protein -
JGZ56_RS03575 813427..814155 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184797 WP_014613364.1 NZ_CP066711:809515-809736 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184797 NZ_CP087806:1601890-1602150 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACCATGACAATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184797 WP_014613363.1 NZ_CP066711:809215-809502 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184797 NZ_CP087806:1602131-1602466 [Moraxella bovis]
ATGAACACCATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References