184794

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 825626..826147 Replicon chromosome
Accession NZ_CP066710
Organism Staphylococcus pseudintermedius strain DSP034

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ11_RS03690 Protein ID WP_014613364.1
Coordinates 825926..826147 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ11_RS03685 Protein ID WP_014613363.1
Coordinates 825626..825913 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ11_RS03660 820887..821690 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JGZ11_RS03665 821680..822318 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ11_RS03670 822407..823273 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ11_RS03675 823327..823983 - 657 WP_199273956.1 HD domain-containing protein -
JGZ11_RS03680 824004..825494 - 1491 WP_014613362.1 cardiolipin synthase -
JGZ11_RS03685 825626..825913 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ11_RS03690 825926..826147 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ11_RS03695 826151..826357 + 207 WP_199273957.1 cation transporter -
JGZ11_RS03700 826458..828638 + 2181 WP_199273958.1 heavy metal translocating P-type ATPase -
JGZ11_RS03705 828724..828870 + 147 WP_014613367.1 hypothetical protein -
JGZ11_RS03710 829837..830565 + 729 WP_199273959.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184794 WP_014613364.1 NZ_CP066710:825926-826147 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184794 NZ_CP087806:699484-699726 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCGTCCGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184794 WP_014613363.1 NZ_CP066710:825626-825913 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184794 NZ_CP087806:699716-699973 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTGATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References