Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 787950..788474 Replicon chromosome
Accession NZ_CP066709
Organism Staphylococcus pseudintermedius strain HSP118

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ29_RS03515 Protein ID WP_014613379.1
Coordinates 788121..788474 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ29_RS03510 Protein ID WP_014613378.1
Coordinates 787950..788120 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ29_RS03485 783839..784312 + 474 WP_099992033.1 PH domain-containing protein -
JGZ29_RS03490 784305..785834 + 1530 WP_199273559.1 PH domain-containing protein -
JGZ29_RS03495 785818..786336 + 519 WP_014613375.1 PH domain-containing protein -
JGZ29_RS03500 786333..786683 + 351 WP_037542556.1 holo-ACP synthase -
JGZ29_RS03505 786717..787865 + 1149 WP_014613377.1 alanine racemase -
JGZ29_RS03510 787950..788120 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ29_RS03515 788121..788474 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ29_RS03520 788532..789535 + 1004 Protein_692 PP2C family protein-serine/threonine phosphatase -
JGZ29_RS03525 789614..789940 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ29_RS03530 789940..790419 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ29_RS03535 790394..791164 + 771 WP_105503168.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184793 WP_014613379.1 NZ_CP066709:788121-788474 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184793 NZ_CP087806:c521564-521286 [Moraxella bovis]
ATGATCTTTGAGTGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184793 WP_014613378.1 NZ_CP066709:787950-788120 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184793 NZ_CP087806:c521299-521012 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References