184791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 815479..816003 Replicon chromosome
Accession NZ_CP066708
Organism Staphylococcus pseudintermedius strain HSP125

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ10_RS03620 Protein ID WP_014613379.1
Coordinates 815650..816003 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ10_RS03615 Protein ID WP_014613378.1
Coordinates 815479..815649 (+) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ10_RS03590 811368..811841 + 474 WP_014613373.1 PH domain-containing protein -
JGZ10_RS03595 811834..813363 + 1530 WP_014613374.1 PH domain-containing protein -
JGZ10_RS03600 813347..813865 + 519 WP_014613375.1 PH domain-containing protein -
JGZ10_RS03605 813862..814212 + 351 WP_014613376.1 holo-ACP synthase -
JGZ10_RS03610 814246..815394 + 1149 WP_014613377.1 alanine racemase -
JGZ10_RS03615 815479..815649 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ10_RS03620 815650..816003 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ10_RS03625 816061..817065 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
JGZ10_RS03630 817144..817470 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ10_RS03635 817470..817949 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ10_RS03640 817924..818694 + 771 WP_014613383.1 RNA polymerase sigma factor SigB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-108)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184791 WP_014613379.1 NZ_CP066708:815650-816003 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184791 NZ_CP087806:300171-300506 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184791 WP_014613378.1 NZ_CP066708:815479-815649 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184791 NZ_CP087806:299929-300171 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7


Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References