Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 815479..816003 | Replicon | chromosome |
Accession | NZ_CP066708 | ||
Organism | Staphylococcus pseudintermedius strain HSP125 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A2A4EDC7 |
Locus tag | JGZ10_RS03620 | Protein ID | WP_014613379.1 |
Coordinates | 815650..816003 (+) | Length | 118 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | A0A166MM16 |
Locus tag | JGZ10_RS03615 | Protein ID | WP_014613378.1 |
Coordinates | 815479..815649 (+) | Length | 57 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JGZ10_RS03590 | 811368..811841 | + | 474 | WP_014613373.1 | PH domain-containing protein | - |
JGZ10_RS03595 | 811834..813363 | + | 1530 | WP_014613374.1 | PH domain-containing protein | - |
JGZ10_RS03600 | 813347..813865 | + | 519 | WP_014613375.1 | PH domain-containing protein | - |
JGZ10_RS03605 | 813862..814212 | + | 351 | WP_014613376.1 | holo-ACP synthase | - |
JGZ10_RS03610 | 814246..815394 | + | 1149 | WP_014613377.1 | alanine racemase | - |
JGZ10_RS03615 | 815479..815649 | + | 171 | WP_014613378.1 | hypothetical protein | Antitoxin |
JGZ10_RS03620 | 815650..816003 | + | 354 | WP_014613379.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
JGZ10_RS03625 | 816061..817065 | + | 1005 | WP_014613380.1 | PP2C family protein-serine/threonine phosphatase | - |
JGZ10_RS03630 | 817144..817470 | + | 327 | WP_014613381.1 | anti-sigma factor antagonist | - |
JGZ10_RS03635 | 817470..817949 | + | 480 | WP_031253870.1 | anti-sigma B factor RsbW | - |
JGZ10_RS03640 | 817924..818694 | + | 771 | WP_014613383.1 | RNA polymerase sigma factor SigB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13130.36 Da Isoelectric Point: 10.4439
>T184791 WP_014613379.1 NZ_CP066708:815650-816003 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK
Download Length: 354 bp
>T184791 NZ_CP087806:300171-300506 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6396.04 Da Isoelectric Point: 3.9930
>AT184791 WP_014613378.1 NZ_CP066708:815479-815649 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED
Download Length: 171 bp
>AT184791 NZ_CP087806:299929-300171 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2A4EDC7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A166MM16 |