184790

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 800563..801084 Replicon chromosome
Accession NZ_CP066708
Organism Staphylococcus pseudintermedius strain HSP125

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ10_RS03545 Protein ID WP_014613364.1
Coordinates 800863..801084 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ10_RS03540 Protein ID WP_014613363.1
Coordinates 800563..800850 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ10_RS03515 795824..796627 + 804 WP_187530673.1 hydroxyethylthiazole kinase -
JGZ10_RS03520 796617..797255 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ10_RS03525 797344..798210 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ10_RS03530 798264..798920 - 657 WP_187530674.1 HD domain-containing protein -
JGZ10_RS03535 798941..800431 - 1491 WP_187530675.1 cardiolipin synthase -
JGZ10_RS03540 800563..800850 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ10_RS03545 800863..801084 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ10_RS03550 801088..801294 + 207 WP_187530676.1 cation transporter -
JGZ10_RS03555 801395..803575 + 2181 WP_115895546.1 heavy metal translocating P-type ATPase -
JGZ10_RS03560 803661..803807 + 147 WP_014613367.1 hypothetical protein -
JGZ10_RS03565 804774..805502 + 729 WP_187530825.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184790 WP_014613364.1 NZ_CP066708:800863-801084 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184790 NZ_CP087806:196467-196868 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTACATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCGTACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184790 WP_014613363.1 NZ_CP066708:800563-800850 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184790 NZ_CP087806:196219-196452 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References