Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 789790..790314 Replicon chromosome
Accession NZ_CP066706
Organism Staphylococcus pseudintermedius strain HSP134

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ55_RS03495 Protein ID WP_014613379.1
Coordinates 789961..790314 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ55_RS03490 Protein ID WP_014613378.1
Coordinates 789790..789960 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ55_RS03465 (JGZ55_03480) 785679..786152 + 474 WP_099992033.1 PH domain-containing protein -
JGZ55_RS03470 (JGZ55_03485) 786145..787674 + 1530 WP_199273559.1 PH domain-containing protein -
JGZ55_RS03475 (JGZ55_03490) 787658..788176 + 519 WP_014613375.1 PH domain-containing protein -
JGZ55_RS03480 (JGZ55_03495) 788173..788523 + 351 WP_037542556.1 holo-ACP synthase -
JGZ55_RS03485 (JGZ55_03500) 788557..789705 + 1149 WP_014613377.1 alanine racemase -
JGZ55_RS03490 (JGZ55_03505) 789790..789960 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JGZ55_RS03495 (JGZ55_03510) 789961..790314 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ55_RS03500 (JGZ55_03515) 790372..791375 + 1004 Protein_687 PP2C family protein-serine/threonine phosphatase -
JGZ55_RS03505 (JGZ55_03520) 791454..791780 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ55_RS03510 (JGZ55_03525) 791780..792259 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ55_RS03515 (JGZ55_03530) 792234..793004 + 771 WP_105503168.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184789 WP_014613379.1 NZ_CP066706:789961-790314 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184789 NZ_CP087806:35799-35987 [Moraxella bovis]
ATGCCCCCAAGTAGCGATGAGATGATAAAGCGAATTACCGAAGACGGTTGGTATTTTGTAAAACAAAAAGGCTCTCACAA
GCACTACAAACACCCAACCAAAGAAGGTAAAGTAACAATCCCAAACGGTCGTGAAAACCTACCCAAAGGAACGCTAAAAA
GCATCATCAAACAAGCAGGGTTGGATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184789 WP_014613378.1 NZ_CP066706:789790-789960 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184789 NZ_CP087806:36050-36457 [Moraxella bovis]
ATGTTATTTCCCATTGCCATTGAAAAACCTGCCAATGAAAACGAATGTTATGGCGTGATTGTGCCAGACATTGCAGGGTG
TTTTAGTGCAGGCGATACACCTGATGAAGCCATTAAGAATGCTTATGAAGCCATCAGTTTGCATTTGGAAGGCATGGCAG
AAGATGGCGATACACTACCTACCGCCAAGCCCATTTTTTATCATCAAGACAATAGCGAATTTGACGGTATGTTGTGGGCA
GTGGTGGACGTGGATATGTCTGCCTTTATGGGTAAGGCGGAGAAAATCAACGTTACCTTGCCAAGCCTACTCATCACCAA
AATTGACGAAAAAGTCTTGTCTCATAAATCGCTATACAAAAGCCGTTCTAATTATTTGGCACAATTGGCGATGGCAGATT
TGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References