Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 774875..775396 Replicon chromosome
Accession NZ_CP066706
Organism Staphylococcus pseudintermedius strain HSP134

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ55_RS03420 Protein ID WP_014613364.1
Coordinates 775175..775396 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ55_RS03415 Protein ID WP_014613363.1
Coordinates 774875..775162 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ55_RS03390 (JGZ55_03405) 770136..770939 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JGZ55_RS03395 (JGZ55_03410) 770929..771567 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ55_RS03400 (JGZ55_03415) 771656..772522 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ55_RS03405 (JGZ55_03420) 772576..773232 - 657 WP_148850674.1 HD domain-containing protein -
JGZ55_RS03410 (JGZ55_03425) 773253..774743 - 1491 WP_014613362.1 cardiolipin synthase -
JGZ55_RS03415 (JGZ55_03430) 774875..775162 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ55_RS03420 (JGZ55_03435) 775175..775396 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
JGZ55_RS03425 (JGZ55_03440) 775400..775606 + 207 WP_014613365.1 cation transporter -
JGZ55_RS03430 (JGZ55_03445) 775707..777887 + 2181 WP_199273556.1 heavy metal translocating P-type ATPase -
JGZ55_RS03435 (JGZ55_03450) 777973..778119 + 147 WP_014613367.1 Lmo0850 family protein -
JGZ55_RS03440 (JGZ55_03455) 779086..779814 + 729 WP_199273557.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184788 WP_014613364.1 NZ_CP066706:775175-775396 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184788 NZ_CP087805:c2240217-2239945 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184788 WP_014613363.1 NZ_CP066706:774875-775162 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184788 NZ_CP087805:c2240503-2240210 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGACTAGACAACGACCTACGCCAAAAAGTCTATCCTGTGCTAGAACAATACGGCTT
GACCCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References