Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 787884..788408 Replicon chromosome
Accession NZ_CP066705
Organism Staphylococcus pseudintermedius strain HSP135

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag JGZ51_RS03520 Protein ID WP_014613379.1
Coordinates 788055..788408 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag JGZ51_RS03515 Protein ID WP_014613378.1
Coordinates 787884..788054 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ51_RS03490 783773..784246 + 474 WP_099992033.1 PH domain-containing protein -
JGZ51_RS03495 784239..785768 + 1530 WP_199273559.1 PH domain-containing protein -
JGZ51_RS03500 785752..786270 + 519 WP_014613375.1 PH domain-containing protein -
JGZ51_RS03505 786267..786617 + 351 WP_037542556.1 holo-ACP synthase -
JGZ51_RS03510 786651..787799 + 1149 WP_014613377.1 alanine racemase -
JGZ51_RS03515 787884..788054 + 171 WP_014613378.1 hypothetical protein Antitoxin
JGZ51_RS03520 788055..788408 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JGZ51_RS03525 788466..789469 + 1004 Protein_694 PP2C family protein-serine/threonine phosphatase -
JGZ51_RS03530 789548..789874 + 327 WP_014613381.1 anti-sigma factor antagonist -
JGZ51_RS03535 789874..790353 + 480 WP_031253870.1 anti-sigma B factor RsbW -
JGZ51_RS03540 790328..791098 + 771 WP_105503168.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T184787 WP_014613379.1 NZ_CP066705:788055-788408 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T184787 NZ_CP087805:c2237123-2236731 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTCTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT184787 WP_014613378.1 NZ_CP066705:787884-788054 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT184787 NZ_CP087805:c2237383-2237120 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References