Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 772969..773490 Replicon chromosome
Accession NZ_CP066705
Organism Staphylococcus pseudintermedius strain HSP135

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ51_RS03445 Protein ID WP_014613364.1
Coordinates 773269..773490 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ51_RS03440 Protein ID WP_014613363.1
Coordinates 772969..773256 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ51_RS03415 768230..769033 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JGZ51_RS03420 769023..769661 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ51_RS03425 769750..770616 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ51_RS03430 770670..771326 - 657 WP_148850674.1 HD domain-containing protein -
JGZ51_RS03435 771347..772837 - 1491 WP_014613362.1 cardiolipin synthase -
JGZ51_RS03440 772969..773256 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ51_RS03445 773269..773490 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ51_RS03450 773494..773700 + 207 WP_014613365.1 cation transporter -
JGZ51_RS03455 773801..775981 + 2181 WP_199273556.1 heavy metal translocating P-type ATPase -
JGZ51_RS03460 776067..776213 + 147 WP_014613367.1 hypothetical protein -
JGZ51_RS03465 777180..777908 + 729 WP_199273557.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184786 WP_014613364.1 NZ_CP066705:773269-773490 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184786 NZ_CP087805:1958730-1958990 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184786 WP_014613363.1 NZ_CP066705:772969-773256 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184786 NZ_CP087805:1958971-1959306 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References