184784

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 773018..773539 Replicon chromosome
Accession NZ_CP066703
Organism Staphylococcus pseudintermedius strain HSP137

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag JGZ48_RS03415 Protein ID WP_014613364.1
Coordinates 773318..773539 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag JGZ48_RS03410 Protein ID WP_014613363.1
Coordinates 773018..773305 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JGZ48_RS03385 768279..769082 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
JGZ48_RS03390 769072..769710 + 639 WP_014613359.1 thiamine phosphate synthase -
JGZ48_RS03395 769799..770665 + 867 WP_014613360.1 membrane protein insertase YidC -
JGZ48_RS03400 770719..771375 - 657 WP_148850674.1 HD domain-containing protein -
JGZ48_RS03405 771396..772886 - 1491 WP_014613362.1 cardiolipin synthase -
JGZ48_RS03410 773018..773305 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
JGZ48_RS03415 773318..773539 + 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
JGZ48_RS03420 773543..773749 + 207 WP_014613365.1 cation transporter -
JGZ48_RS03425 773850..776030 + 2181 WP_199273556.1 heavy metal translocating P-type ATPase -
JGZ48_RS03435 777229..777957 + 729 WP_199273557.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T184784 WP_014613364.1 NZ_CP066703:773318-773539 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T184784 NZ_CP087805:c1435221-1434964 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT184784 WP_014613363.1 NZ_CP066703:773018-773305 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT184784 NZ_CP087805:c1435453-1435211 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References