Detailed information of TA system TA184781

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 4673408..4674060
• Replicon: chromosome
• Accession: NZ_CP066699
• Organism: Rhodopseudomonas palustris strain RCB100

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q6N2A8
• Locus tag: I8G32_RS21350
• Protein ID: WP_011159677.1
• Coordinates: 4673656..4674060 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q6N2A9
• Locus tag: I8G32_RS21345
• Protein ID: WP_011159676.1
• Coordinates: 4673408..4673659 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8G32_RS21335	4668570..4668953	-	384	WP_011159673.1	phasin	-
I8G32_RS21340	4669278..4672859	+	3582	WP_042441275.1	PAS domain-containing protein	-
I8G32_RS21345	4673408..4673659	+	252	WP_011159676.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I8G32_RS21350	4673656..4674060	+	405	WP_011159677.1	type II toxin-antitoxin system VapC family toxin	Toxin
I8G32_RS21355	4674144..4674854	+	711	WP_011159678.1	Crp/Fnr family transcriptional regulator	-
I8G32_RS21360	4674827..4675051	-	225	WP_011159679.1	DUF1858 domain-containing protein	-
I8G32_RS21365	4675289..4676401	+	1113	WP_011159680.1	nitrite reductase, copper-containing	-
I8G32_RS21370	4676570..4677451	+	882	WP_011159681.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14406.53 Da
• Isoelectric Point: 4.8780

>T184781 WP_011159677.1 NZ_CP066699:4673656-4674060 [Rhodopseudomonas palustris]
VIVIDTSAIIAIFREEPEAAQFARLIASDDQPVLSSGNLLETAIVLRGLKDIQPAKAERWLDDFIAEAGIRIEPVTTEQA
GYARSAHLRFGKGTGHKAALNYGDCFAYALAKALNAPLLCKGNDFPLTDIPLVA

Nucleotide

• Length: 405 bp

>T184781 NZ_CP087805:649030-649431 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTGCATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCATACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9293.42 Da
• Isoelectric Point: 6.7249

>AT184781 WP_011159676.1 NZ_CP066699:4673408-4673659 [Rhodopseudomonas palustris]
MHLNIKNDEAHQLATELARMTGESLTAAVTNALREQLAREHRRRQTDQIAQRLLKIGGRYAALPDTGRTPDEILGYDENG
LPT

Nucleotide

• Length: 252 bp

>AT184781 NZ_CP087805:648782-649015 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA

Structures

Toxin

• AlphaFold DB: Q6N2A8

Antitoxin

• AlphaFold DB: Q6N2A9