Detailed information of TA system TA184777

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2232201..2232871
• Replicon: chromosome
• Accession: NZ_CP066699
• Organism: Rhodopseudomonas palustris strain RCB100

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q6N8B2
• Locus tag: I8G32_RS10195
• Protein ID: WP_011157547.1
• Coordinates: 2232201..2232611 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I8G32_RS10200
• Protein ID: WP_011157548.1
• Coordinates: 2232608..2232871 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8G32_RS10180	2228590..2228916	+	327	WP_011157544.1	hypothetical protein	-
I8G32_RS10185	2229083..2230873	+	1791	WP_011157545.1	sulfatase-like hydrolase/transferase	-
I8G32_RS10190	2230909..2231946	+	1038	WP_042441504.1	transporter	-
I8G32_RS10195	2232201..2232611	-	411	WP_011157547.1	type II toxin-antitoxin system VapC family toxin	Toxin
I8G32_RS10200	2232608..2232871	-	264	WP_011157548.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
I8G32_RS10205	2233052..2233477	+	426	WP_011157549.1	cupin domain-containing protein	-
I8G32_RS10210	2233574..2234743	-	1170	WP_011157550.1	DUF2865 domain-containing protein	-
I8G32_RS10215	2234929..2235237	-	309	WP_011157551.1	hypothetical protein	-
I8G32_RS10220	2235638..2237029	+	1392	WP_011157552.1	cysteine--tRNA ligase	-
I8G32_RS10225	2237026..2237562	+	537	WP_147408398.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (9-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15136.48 Da
• Isoelectric Point: 5.6802

>T184777 WP_011157547.1 NZ_CP066699:c2232611-2232201 [Rhodopseudomonas palustris]
MSGWMLDTNVASHVIRGDRREIIERLVALPISDVVISSITEGELLYGLAKRGYPTALSERVREFLLRVDVLPWDHEVTKT
YADLRAVCEAKGVTLSPLDMMIAAHAAATNATLVTRDKAFSRVPSPLRIEDWAEMS

Nucleotide

• Length: 411 bp

>T184777 NZ_CP087803:c2017895-2017560 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9888.91 Da
• Isoelectric Point: 4.7969

>AT184777 WP_011157548.1 NZ_CP066699:c2232871-2232608 [Rhodopseudomonas palustris]
VTSRTAKIFTTGRSQAVRLPAEFRFEGSEVFVRRDPRTGDVILSRKPDSWDGLLQLHQSADVPDDFLGPSDRSQLPQDRD
PFEGWTE

Nucleotide

• Length: 264 bp

>AT184777 NZ_CP087803:c2018137-2017895 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Structures

Toxin

• AlphaFold DB: Q6N8B2