Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 18676..19195 Replicon plasmid p2
Accession NZ_CP066675
Organism Enterococcus faecium strain Dallas 163_1

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP82_RS14970 Protein ID WP_000588503.1
Coordinates 18938..19195 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP82_RS14965 Protein ID WP_000388479.1
Coordinates 18676..18945 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP82_RS14940 15242..15436 + 195 WP_198995318.1 hypothetical protein -
JCP82_RS14945 15470..16150 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP82_RS14950 16663..17343 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP82_RS14955 17419..17985 + 567 Protein_21 hypothetical protein -
JCP82_RS14960 18366..18545 + 180 WP_001120991.1 hypothetical protein -
JCP82_RS14965 18676..18945 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP82_RS14970 18938..19195 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP82_RS14975 19654..20658 + 1005 WP_000455809.1 hypothetical protein -
JCP82_RS14980 20823..21437 - 615 WP_001261742.1 recombinase family protein -
JCP82_RS14985 21887..23212 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP82_RS14990 23205..23555 + 351 WP_000568378.1 hypothetical protein -
JCP82_RS14995 23552..23731 + 180 WP_001021554.1 hypothetical protein -
JCP82_RS15000 23867..24157 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(6)-Ia / aph(3')-III - 1..25974 25974


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184775 WP_000588503.1 NZ_CP066675:18938-19195 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184775 NZ_CP087803:1796606-1796884 [Moraxella bovis]
ATGATCTTTGAGTGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184775 WP_000388479.1 NZ_CP066675:18676-18945 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184775 NZ_CP087803:1796871-1797158 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References