Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 48490..49009 Replicon plasmid p3
Accession NZ_CP066662
Organism Enterococcus faecium strain Dallas 155

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP86_RS15635 Protein ID WP_000588503.1
Coordinates 48752..49009 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP86_RS15630 Protein ID WP_000388479.1
Coordinates 48490..48759 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP86_RS15605 44014..44586 + 573 WP_000170424.1 recombinase family protein -
JCP86_RS15610 44648..45328 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP86_RS15615 45433..46032 + 600 WP_011117472.1 hypothetical protein -
JCP86_RS15620 46321..47571 - 1251 WP_002305888.1 IS110 family transposase -
JCP86_RS15625 48180..48359 + 180 WP_001120991.1 hypothetical protein -
JCP86_RS15630 48490..48759 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP86_RS15635 48752..49009 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP86_RS15640 49468..50472 + 1005 WP_000455809.1 hypothetical protein -
JCP86_RS15645 50637..51251 - 615 WP_002318230.1 recombinase family protein -
JCP86_RS15650 51701..53026 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP86_RS15655 53019..53369 + 351 WP_000568378.1 hypothetical protein -
JCP86_RS15660 53681..53971 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..57134 57134


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184769 WP_000588503.1 NZ_CP066662:48752-49009 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184769 NZ_CP087803:467129-467401 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184769 WP_000388479.1 NZ_CP066662:48490-48759 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184769 NZ_CP087803:466843-467136 [Moraxella bovis]
ATGAGCCGCACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACCCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References