Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 38667..39186 Replicon plasmid p148_45kb
Accession NZ_CP066649
Organism Enterococcus faecium strain Dallas 148

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP76_RS15415 Protein ID WP_000588503.1
Coordinates 38929..39186 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP76_RS15410 Protein ID WP_000388479.1
Coordinates 38667..38936 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP76_RS15385 33939..35416 + 1478 Protein_37 type I restriction-modification system subunit M -
JCP76_RS15390 35439..36119 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP76_RS15395 36654..37334 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP76_RS15400 37410..37976 + 567 Protein_40 hypothetical protein -
JCP76_RS15405 38357..38536 + 180 WP_001120991.1 hypothetical protein -
JCP76_RS15410 38667..38936 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP76_RS15415 38929..39186 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP76_RS15420 39645..40649 + 1005 WP_000455809.1 hypothetical protein -
JCP76_RS15425 40814..41428 - 615 WP_001261742.1 recombinase family protein -
JCP76_RS15430 41878..43203 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP76_RS15435 43196..43546 + 351 WP_000568378.1 hypothetical protein -
JCP76_RS15440 43543..43722 + 180 WP_001021554.1 hypothetical protein -
JCP76_RS15445 43858..44148 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..45965 45965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184762 WP_000588503.1 NZ_CP066649:38929-39186 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184762 NZ_CP087800:1744567-1744845 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184762 WP_000388479.1 NZ_CP066649:38667-38936 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184762 NZ_CP087800:1744832-1745119 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References