Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 22082..22601 Replicon plasmid p144_1_47kb
Accession NZ_CP066641
Organism Enterococcus faecium strain Dallas 144_1

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP95_RS15700 Protein ID WP_000588503.1
Coordinates 22082..22339 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP95_RS15705 Protein ID WP_000388479.1
Coordinates 22332..22601 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP95_RS15670 17904..18320 - 417 WP_002305824.1 hypothetical protein -
JCP95_RS15675 18322..18603 - 282 WP_000353845.1 hypothetical protein -
JCP95_RS15680 18979..19503 - 525 WP_002305828.1 DUF536 domain-containing protein -
JCP95_RS15685 19520..20386 - 867 WP_010729550.1 replication initiation protein -
JCP95_RS15690 20457..21137 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP95_RS15695 21213..21623 - 411 Protein_23 hypothetical protein -
JCP95_RS15700 22082..22339 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP95_RS15705 22332..22601 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP95_RS15710 22732..22911 - 180 WP_001120991.1 hypothetical protein -
JCP95_RS15715 23452..24132 + 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP95_RS15720 24667..25347 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP95_RS15725 25403..26848 - 1446 Protein_29 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..47773 47773
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..41802 40145


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184756 WP_000588503.1 NZ_CP066641:c22339-22082 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184756 NZ_CP087800:436224-436496 [Moraxella bovis]
GTGGCTAAACGTAGTTTTGAAATGGGCAATCCCTTTAAAAGGGATTTAAAAAAGCATTATTTGGCATTGATTGGCGAAGC
GTGGACGGAAGTGTCTGATTGCTTGTTAAATGCCAAACCCATACCTCAAAAATACCAAGACCACCCATTGCAAGGCGATT
GGGTGGGGTTTAGAGATTGTCATATCAAGCCTGATTTGGTGCTAATTTATAAAATAAATGATGAAGCGGTGGAATTACAT
CGGCTTGCCACGCATAGCGAGTTGTTTGGTTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184756 WP_000388479.1 NZ_CP066641:c22601-22332 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184756 NZ_CP087800:435938-436231 [Moraxella bovis]
ATGAGCCACACCAATTTTAATATGCGATTAGACAACGACCTACGCCAAAAAGCCTATCCTGTGCTAGAACAATACGGCTT
GACTCCAAGCCAAGCAGTGCGGATGTTTTTTAATCAAATCGCCCAAACAGGCAAAGTGCCATTGTCTTTTGATTGGGGGC
AGTCGCATACGCTTAGTAGCAATGGCGAAAAGCTGTTGCGTGAGAGTATTCAAGCTTTTGAAAATGGCGAAACCGAGCGA
TTTGATAGCTTAGATGAGTTAAATCAAGCAATGGCGGAGATTGCTCGTGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References