Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1650579..1651254 Replicon chromosome
Accession NZ_CP066637
Organism Enterococcus faecium strain Dallas 144_1

Toxin (Protein)


Gene name hicA Uniprot ID A0A430A2J6
Locus tag JCP95_RS08030 Protein ID WP_002350171.1
Coordinates 1651072..1651254 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A430A2G3
Locus tag JCP95_RS08025 Protein ID WP_042958047.1
Coordinates 1650579..1651034 (-) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP95_RS08010 1647233..1647658 - 426 WP_161569018.1 TnpV protein -
JCP95_RS08015 1648389..1649972 - 1584 WP_002350174.1 DUF3991 domain-containing protein -
JCP95_RS08020 1650044..1650484 - 441 WP_199017936.1 hypothetical protein -
JCP95_RS08025 1650579..1651034 - 456 WP_042958047.1 HicB family protein Antitoxin
JCP95_RS08030 1651072..1651254 - 183 WP_002350171.1 type II toxin-antitoxin system HicA family toxin Toxin
JCP95_RS08035 1651324..1652565 - 1242 WP_002350170.1 hypothetical protein -
JCP95_RS08040 1652568..1653116 - 549 WP_002350169.1 hypothetical protein -
JCP95_RS08045 1653116..1653373 - 258 WP_002350168.1 ribbon-helix-helix protein, CopG family -
JCP95_RS08050 1653736..1654551 - 816 WP_002350167.1 hypothetical protein -
JCP95_RS08055 1654573..1654863 - 291 WP_042958053.1 thioredoxin family protein -
JCP95_RS08060 1655004..1655618 - 615 WP_002350165.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(18-116)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6498.85 Da        Isoelectric Point: 11.3109

>T184752 WP_002350171.1 NZ_CP066637:c1651254-1651072 [Enterococcus faecium]
MPMTQNEMVKLLIEHGGVKVKGGKGSHIKVRFPGVNRPIIVPQKLPKGTENGILKQAGLK

Download         Length: 183 bp

>T184752 NZ_CP087798:c2028138-2027803 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 16865.84 Da        Isoelectric Point: 4.0033

>AT184752 WP_042958047.1 NZ_CP066637:c1651034-1650579 [Enterococcus faecium]
MLVSYPALFYFENSEGYDPGFSVFFPDFPNTGGTSGSTISEALEMASDYLGILLSDDIEQERELPKPSLISSLSLEENDP
FKDDSDFNFEYDFEKSFVSMVSVDLSQYLGNNDPIKKTLTIPKWADKLGKDLHLNFSKTLTDAIVSKKMGA

Download         Length: 456 bp

>AT184752 NZ_CP087798:c2028380-2028138 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A430A2J6

Antitoxin

Source ID Structure
AlphaFold DB A0A430A2G3

References