Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 218093..218622 | Replicon | chromosome |
Accession | NZ_CP066622 | ||
Organism | Enterococcus faecium strain Dallas 131_2 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q3XX67 |
Locus tag | JCP79_RS01075 | Protein ID | WP_002296560.1 |
Coordinates | 218356..218622 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A829F3T0 |
Locus tag | JCP79_RS01070 | Protein ID | WP_002296559.1 |
Coordinates | 218093..218356 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JCP79_RS01060 | 215467..217290 | + | 1824 | WP_002294202.1 | APC family permease | - |
JCP79_RS01065 | 217432..217617 | - | 186 | WP_002296558.1 | transcriptional regulator | - |
JCP79_RS01070 | 218093..218356 | + | 264 | WP_002296559.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
JCP79_RS01075 | 218356..218622 | + | 267 | WP_002296560.1 | Txe/YoeB family addiction module toxin | Toxin |
JCP79_RS01080 | 218823..219311 | + | 489 | WP_002296561.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
JCP79_RS01085 | 219852..220523 | - | 672 | WP_002302663.1 | ABC transporter permease | - |
JCP79_RS01090 | 220520..221437 | - | 918 | WP_002296564.1 | osmoprotectant ABC transporter substrate-binding protein | - |
JCP79_RS01095 | 221434..222075 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
JCP79_RS01100 | 222079..223254 | - | 1176 | WP_002294192.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10660.13 Da Isoelectric Point: 9.9931
>T184741 WP_002296560.1 NZ_CP066622:218356-218622 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T184741 NZ_CP087796:c1978269-1977868 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTGCATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCATACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA
ATGTTTAGTTTTATGCTGGATACCAATATCTGCATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCATACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10046.05 Da Isoelectric Point: 4.1207
>AT184741 WP_002296559.1 NZ_CP066622:218093-218356 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
Download Length: 264 bp
>AT184741 NZ_CP087796:c1978517-1978284 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FCW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F3T0 |