Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 30581..31100 Replicon plasmid p124_3_37kb
Accession NZ_CP066617
Organism Enterococcus faecium strain Dallas 124_3

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP92_RS15275 Protein ID WP_000588503.1
Coordinates 30843..31100 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP92_RS15270 Protein ID WP_000388479.1
Coordinates 30581..30850 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP92_RS15235 26151..26567 - 417 WP_001232859.1 hypothetical protein -
JCP92_RS15240 26570..26854 - 285 WP_000353844.1 hypothetical protein -
JCP92_RS15245 27200..27445 + 246 WP_002311817.1 hypothetical protein -
JCP92_RS15250 27747..27842 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
JCP92_RS15255 28568..29248 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP92_RS15260 29324..29890 + 567 Protein_37 hypothetical protein -
JCP92_RS15265 30271..30450 + 180 WP_001120991.1 hypothetical protein -
JCP92_RS15270 30581..30850 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP92_RS15275 30843..31100 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP92_RS15280 31737..32561 + 825 WP_001809248.1 hypothetical protein -
JCP92_RS15285 32726..33340 - 615 WP_001261742.1 recombinase family protein -
JCP92_RS15290 33790..35115 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP92_RS15295 35108..35458 + 351 WP_000568378.1 hypothetical protein -
JCP92_RS15300 35455..35634 + 180 WP_001021554.1 hypothetical protein -
JCP92_RS15305 35770..36060 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / aph(3')-III / VanHAX - 1..37877 37877


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184740 WP_000588503.1 NZ_CP066617:30843-31100 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184740 NZ_CP087796:c1860920-1860585 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184740 WP_000388479.1 NZ_CP066617:30581-30850 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184740 NZ_CP087796:c1861162-1860920 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCCGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References