Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 515193..515764 Replicon chromosome
Accession NZ_CP066591
Organism Enterococcus faecium strain Dallas 107_1

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag JCQ02_RS02465 Protein ID WP_002286801.1
Coordinates 515423..515764 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag JCQ02_RS02460 Protein ID WP_002323011.1
Coordinates 515193..515423 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCQ02_RS02430 510326..511657 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
JCQ02_RS02435 511679..512305 + 627 WP_002286816.1 cysteine hydrolase -
JCQ02_RS02440 512488..513069 + 582 WP_010729547.1 TetR/AcrR family transcriptional regulator -
JCQ02_RS02445 513801..514148 + 348 WP_002286808.1 SOS response-associated peptidase family protein -
JCQ02_RS02450 514124..514363 + 240 WP_002321938.1 SOS response-associated peptidase family protein -
JCQ02_RS02455 514568..514906 - 339 WP_002286804.1 hypothetical protein -
JCQ02_RS02460 515193..515423 + 231 WP_002323011.1 hypothetical protein Antitoxin
JCQ02_RS02465 515423..515764 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JCQ02_RS02470 516614..516799 + 186 WP_002304207.1 hypothetical protein -
JCQ02_RS02475 517304..517498 + 195 WP_002297028.1 hypothetical protein -
JCQ02_RS02480 517656..517938 + 283 Protein_493 transposase -
JCQ02_RS02485 518182..519012 - 831 WP_002286789.1 manganese catalase family protein -
JCQ02_RS02490 519220..520554 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T184720 WP_002286801.1 NZ_CP066591:515423-515764 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T184720 NZ_CP087791:c2250416-2250024 [Moraxella bovis]
ATGAAATATTTGCTGGACACCAATGCAGTCATTGCGATTTTGAATGCCAGTGAACGATTTTTGACCACGCTAGAACGGCA
TAAAGAGCGTGAAATTGCCATCTCGTCAATTGTTTTGTCGGAGCTGTATTATGGGGCGTACAAAAGCCAAAAAACCGCCC
AAAACCTTGAAAAAATCAATCTACTACCCTTTGAAGTGTTGCAATTTAATTCACAGGACGCTGATAAGGCTGGCGAAATT
GGTGCAACCCTAGAAAGGCGTGGCACACCCATTGGTTCTTATGACACGCTGATTGCAGGGCAAGCGATTGCCAATGATTT
GATTGTTATTACTGACAATGTGCGAGAATTTCTCCGAGTGGACGGTTTGCAAATTGAAAATTGGTTAAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT184720 WP_002323011.1 NZ_CP066591:515193-515423 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT184720 NZ_CP087791:c2250676-2250413 [Moraxella bovis]
ATGCGCCAAACTGCCACCGCAAAATTATTTTGGACTGGCAACAGTCAAGCCGTTCGCTTACCCAAAGCCTTTCGTTTTGA
AGGCACGGAAGTGCGTATCAAAAAACAAGGACGACAAGTGATTATTGAGCCAGCAGAGACCCAAGATTGGGCGTGGCTGG
ACAAATTGCGAGCAATGCCAAAAGATGACAGTTTTGAAGAAGCCATTTTGGAAGGTCGCCAAAATTTAAAAGCCGATGAA
CGAGATTGGGGTGCATTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References