184715

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 22699..23218 Replicon plasmid p103_48kb
Accession NZ_CP066586
Organism Enterococcus faecium strain Dallas 103

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP83_RS15040 Protein ID WP_000588503.1
Coordinates 22961..23218 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP83_RS15035 Protein ID WP_000388479.1
Coordinates 22699..22968 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP83_RS15005 18015..18539 - 525 WP_002305828.1 DUF536 domain-containing protein -
JCP83_RS15010 18556..19422 - 867 WP_199021958.1 replication initiation protein -
JCP83_RS15015 19493..20173 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP83_RS15020 20686..21366 - 681 WP_002287920.1 IS6-like element IS1216 family transposase -
JCP83_RS15025 21442..22008 + 567 Protein_28 hypothetical protein -
JCP83_RS15030 22389..22568 + 180 WP_001120991.1 hypothetical protein -
JCP83_RS15035 22699..22968 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP83_RS15040 22961..23218 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP83_RS15045 23677..24462 + 786 Protein_32 hypothetical protein -
JCP83_RS15050 24537..25217 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP83_RS15055 25240..26717 - 1478 Protein_34 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..48758 48758
- inside IScluster/Tn VanHAX - 19493..46829 27336


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184715 WP_000588503.1 NZ_CP066586:22961-23218 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184715 NZ_CP087791:1289738-1290016 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184715 WP_000388479.1 NZ_CP066586:22699-22968 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184715 NZ_CP087791:1290046-1290336 [Moraxella bovis]
ATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGCCACCGCCTTAGCAAA
TGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTGATACCGCTTTGCGTT
TGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGCCTTGCCGAAACTACG
CTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References