184714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 505957..506528 Replicon chromosome
Accession NZ_CP066583
Organism Enterococcus faecium strain Dallas 103

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag JCP83_RS02405 Protein ID WP_002286801.1
Coordinates 506187..506528 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag JCP83_RS02400 Protein ID WP_002323011.1
Coordinates 505957..506187 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP83_RS02370 501090..502421 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
JCP83_RS02375 502443..503069 + 627 WP_002286816.1 cysteine hydrolase -
JCP83_RS02380 503252..503833 + 582 WP_010729547.1 TetR/AcrR family transcriptional regulator -
JCP83_RS02385 504565..504912 + 348 WP_002286808.1 SOS response-associated peptidase family protein -
JCP83_RS02390 504888..505127 + 240 WP_002321938.1 SOS response-associated peptidase family protein -
JCP83_RS02395 505332..505670 - 339 WP_002286804.1 hypothetical protein -
JCP83_RS02400 505957..506187 + 231 WP_002323011.1 hypothetical protein Antitoxin
JCP83_RS02405 506187..506528 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JCP83_RS02410 507378..507563 + 186 WP_002304207.1 hypothetical protein -
JCP83_RS02415 508068..508262 + 195 WP_002297028.1 hypothetical protein -
JCP83_RS02420 508420..508702 + 283 Protein_481 transposase -
JCP83_RS02425 508946..509776 - 831 WP_002286789.1 manganese catalase family protein -
JCP83_RS02430 509984..511318 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T184714 WP_002286801.1 NZ_CP066583:506187-506528 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T184714 NZ_CP087791:c925766-925488 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT184714 WP_002323011.1 NZ_CP066583:505957-506187 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT184714 NZ_CP087791:c925501-925214 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References