Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 504157..504728 Replicon chromosome
Accession NZ_CP066576
Organism Enterococcus faecium strain Dallas 100_1

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag JCP75_RS02410 Protein ID WP_002286801.1
Coordinates 504387..504728 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag JCP75_RS02405 Protein ID WP_002323011.1
Coordinates 504157..504387 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP75_RS02375 499290..500621 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
JCP75_RS02380 500643..501269 + 627 WP_002286816.1 cysteine hydrolase -
JCP75_RS02385 501452..502033 + 582 WP_010729547.1 TetR/AcrR family transcriptional regulator -
JCP75_RS02390 502765..503112 + 348 WP_002286808.1 SOS response-associated peptidase family protein -
JCP75_RS02395 503088..503327 + 240 WP_002321938.1 SOS response-associated peptidase family protein -
JCP75_RS02400 503532..503870 - 339 WP_002286804.1 hypothetical protein -
JCP75_RS02405 504157..504387 + 231 WP_002323011.1 hypothetical protein Antitoxin
JCP75_RS02410 504387..504728 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JCP75_RS02415 505578..505763 + 186 WP_002304207.1 hypothetical protein -
JCP75_RS02420 506268..506462 + 195 WP_002297028.1 hypothetical protein -
JCP75_RS02425 506620..506902 + 283 Protein_482 transposase -
JCP75_RS02430 507146..507976 - 831 WP_002286789.1 manganese catalase family protein -
JCP75_RS02435 508184..509518 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T184709 WP_002286801.1 NZ_CP066576:504387-504728 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

>T184709 NZ_CP087784:c2090825-2090424 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTACATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCGTACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT184709 WP_002323011.1 NZ_CP066576:504157-504387 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp

>AT184709 NZ_CP087784:c2091073-2090840 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References