Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 203568..204097 | Replicon | chromosome |
Accession | NZ_CP066576 | ||
Organism | Enterococcus faecium strain Dallas 100_1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q3XX67 |
Locus tag | JCP75_RS01010 | Protein ID | WP_002296560.1 |
Coordinates | 203831..204097 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A829F3T0 |
Locus tag | JCP75_RS01005 | Protein ID | WP_002296559.1 |
Coordinates | 203568..203831 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JCP75_RS00995 | 200942..202765 | + | 1824 | WP_002294202.1 | APC family permease | - |
JCP75_RS01000 | 202907..203092 | - | 186 | WP_002296558.1 | transcriptional regulator | - |
JCP75_RS01005 | 203568..203831 | + | 264 | WP_002296559.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
JCP75_RS01010 | 203831..204097 | + | 267 | WP_002296560.1 | Txe/YoeB family addiction module toxin | Toxin |
JCP75_RS01015 | 204298..204786 | + | 489 | WP_002296561.1 | mannosyl-glycoprotein endo-beta-N-acetylglucosamidase | - |
JCP75_RS01020 | 205327..205998 | - | 672 | WP_002302663.1 | ABC transporter permease | - |
JCP75_RS01025 | 205995..206912 | - | 918 | WP_002296564.1 | osmoprotectant ABC transporter substrate-binding protein | - |
JCP75_RS01030 | 206909..207550 | - | 642 | WP_002293405.1 | ABC transporter permease | - |
JCP75_RS01035 | 207554..208729 | - | 1176 | WP_002294192.1 | betaine/proline/choline family ABC transporter ATP-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10660.13 Da Isoelectric Point: 9.9931
>T184708 WP_002296560.1 NZ_CP066576:203831-204097 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE
Download Length: 267 bp
>T184708 NZ_CP087784:c1986077-1985742 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 10046.05 Da Isoelectric Point: 4.1207
>AT184708 WP_002296559.1 NZ_CP066576:203568-203831 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL
Download Length: 264 bp
>AT184708 NZ_CP087784:c1986319-1986077 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCTGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829FCW8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F3T0 |