Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 31367..31886 Replicon plasmid p97_1_39kb
Accession NZ_CP066571
Organism Enterococcus faecium strain Dallas 97_1

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag JCP88_RS15715 Protein ID WP_000588503.1
Coordinates 31629..31886 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag JCP88_RS15710 Protein ID WP_000388479.1
Coordinates 31367..31636 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JCP88_RS15685 26947..28362 + 1416 WP_002303405.1 plasmid recombination protein -
JCP88_RS15690 28811..29299 + 489 Protein_34 replication protein -
JCP88_RS15695 29354..30034 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
JCP88_RS15700 30110..30676 + 567 Protein_36 hypothetical protein -
JCP88_RS15705 31057..31236 + 180 WP_001120991.1 hypothetical protein -
JCP88_RS15710 31367..31636 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JCP88_RS15715 31629..31886 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
JCP88_RS15720 32345..33349 + 1005 WP_000455809.1 hypothetical protein -
JCP88_RS15725 33514..34128 - 615 WP_001261742.1 recombinase family protein -
JCP88_RS15730 34578..35903 + 1326 WP_000969590.1 Y-family DNA polymerase -
JCP88_RS15735 35896..36246 + 351 WP_000568378.1 hypothetical protein -
JCP88_RS15740 36243..36422 + 180 WP_001021554.1 hypothetical protein -
JCP88_RS15745 36558..36848 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) / VanHAX - 1..39713 39713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T184707 WP_000588503.1 NZ_CP066571:31629-31886 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T184707 NZ_CP087784:1817395-1817673 [Moraxella bovis]
ATGATTCAAAGTTTTAAGTGCAAAGATGCCCAAAGCCTGTTTGAAACAGGGTCAAGCCGTGTATTTGCCAACTTTTTATC
CGTTGCCACTCGCAAACTTACCATGCTTGATAATGCCGTGGCACTTGCCGACCTACGCATTCCACCTGCCAACCGCCTTG
AAAAGCTGACAGGCGATAGAGAAGGTCAGTATAGTATTCGCATTAACGACCAATTTCGCATTTGCTTTGTGTGGGGCGAT
GATGGCGTGTATGATGTTGAGATTGTTGATTATCACTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT184707 WP_000388479.1 NZ_CP066571:31367-31636 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT184707 NZ_CP087784:1817688-1817993 [Moraxella bovis]
ATGTTCAAAAATGGCATGAGACCTGTTCACGCAGGTGAGGTATTGCGTGAAGAATATCTAATCCCAATGGGTATGTCCGC
CACCGCCTTAGCAAATGCATTGGGCGTAACCCCTGCACGCATTAACGACATCGTGCGGCAGCGGCGTGGCGTTACGGCTG
ATACCGCTTTGCGTTTGGCTCGTTATTTTGGCGGTACGGCACAATTTTGGCTAAACTTACAAACCACCTATGAGCTTCGC
CTTGCCGAAACTACGCTTGGCGACAGTTTGGATTTTATCAGCCCTCATGAAGTTGCCCATGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References